Cytoskeleton-associated cell contacts
Cytoskeleton-associated cell contacts
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DOI：
10.1016/s0955-0674(89)80045-6
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发表时间：
1989-02-01
影响因子：
7.5
通讯作者：
Geiger, B.
中科院分区：
文献类型：
--
作者：
Geiger, B.
多细胞生命的最显著特征之一是其组成细胞彼此之间以及与互连的细胞外基质（ECM）的频繁和有序的相互作用。这种粘附相互作用已经被认识和描述了几十年，并且无疑涉及广泛的细胞和发育过程，例如组织形态发生和重塑、引导细胞迁移、上皮屏障的形成、极性的获得等。此外，最近大量令人信服的证据表明细胞粘附在细胞程序性分化中的关键作用。因此，细胞接触区域似乎不仅是细胞机械锚定的位点，而且是信号传递的特定膜结构域，影响细胞运动性、生长和分化。参与这一过程的配体和膜受体的性质，以及在接触位点中这种跨膜信号传导的分子基础，最近已成为该领域的主要研究课题。细胞粘附的一些表现，包括接触位点的形态，细胞外表面的拓扑学和化学以及细胞粘附的后果以及“接触”家族的鉴定在过去的几年中，已经描述了“细胞受体”（Obrink，Exp Cell Res 1986，163：1-21; Edelman和Thiery，eds，The Cell in Contact. John Wiley and Sons，1986）[1-7].在本文中，我想重点关注最近的发展，主要讨论接触区域中常见的跨膜相互作用。正如下面将要讨论的，典型的跨膜相互作用发生在细胞接触中，在那里它们经常显示出与细胞骨架元件的特异性关联。特别是，这种相互作用在与肌动蛋白相关的粘附连接（AJ）中很明显[8]。最近的研究集中在这些方面处理的表征的分子成分的这种接触，其特异性和模式的结合到外表面或细胞骨架。据信，这些相互作用不仅稳定和机械调节细胞接触的形成，而且还具有主要的长期和长期参与形态发生和发育事件。
One of the most prominent features of multicellular life is the frequent and ordered interactions of their constituent cells with each other and with the interconnecting extracellular matrix (ECM). Such adhesive interactions have been recognized and described for several decades and are undoubtedly involved in a broad spectrum of cellular and developmental processes such as tissue morphogenesis and remodelling, guided cell migration, formation of epithelial barriers, acquisition of polarity, etc. Moreover, a compelling body of recent evidence pointed to the critical role of cell adhesion in the programmed differentiation of cells. Thus, areas of cell contact appear to be not only sites through which the cells are mechanically anchored, but also specific membrane domains through which signals are transmitted, affecting cell motility, growth and differentiation. The nature of the ligands and membrane receptors involved in this process, as well as the molecular basis for this transmembrane signalling in contact sites, have recently become major topics of interest in this field.Some of the manifestations of cell adhesion, including the morphology of contact sites, the topology and chemistry of the extracellular surface and the consequences of cell adhesion as well as the identification of families of'contact receptors', have been described over the last several years (Obrink, Exp Cell Res 1986, 163: 1-21; Edelman and Thiery, eds, The Cell in Contact. John Wiley and Sons, 1986)[1-7]. In this article, I would like to focus on recent developments, addressing mainly transmembrane interactions which commonly occur in areas of contact. As will be discussed below, typical transmembrane interactions occur in cell contacts where they often show specific association with cytoskeletal elements. In particular, such interactions are apparent in adherens junctions (AJ) which are associated with actin [8]. Recent studies focusing on these aspects deal with the characterization of the molecular constituents of such contacts, their specificity and mode of binding to the external surface or to the cytoskeleton. It is believed that these interactions do not only stabilize and mechanically regulate cell contact formation, but also have a major long-range and longterm involvement in morphogenetic and developmental events.