Semantic processes leading to true and false memory formation in schizophrenia.
Semantic processes leading to true and false memory formation in schizophrenia.
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DOI：
10.1016/j.schres.2013.04.007
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发表时间：
2013-07
影响因子：
4.5
通讯作者：
Ragland JD
中科院分区：
文献类型：
--
作者：
Paz-Alonso PM;Ghetti S;Ramsay I;Solomon M;Yoon J;Carter CS;Ragland JD
对单词列表上的项目之间的语义关系进行编码（语义处理）可以增强真实的记忆，但也会增加记忆失真。精神分裂症（SZ）的情节记忆障碍是由语义关系处理失败引起的，但这些关系语义处理缺陷的确切性质还没有得到很好的理解。在这里，我们使用了一个错误的记忆范式，调查的影响，内隐和外显的语义加工操纵的情景记忆在深圳。30名SZ和30名人口统计学匹配的健康对照（HC）研究了Deese/Roediger-McDermott（DRM）语义相关词列表。一半的列表有很强的隐含语义关联，其余的关联强度较低。同样，一半的列表是在“标准”指令下呈现的，另一半是在明确的“关系处理”指令下呈现的。研究结束后，参与者进行回忆和旧/新的识别测试组成的目标，关键的诱惑，和无关的诱惑。与SZ相比，HC表现出更高的真实记忆和更好的真假记忆辨别力。高，与低，联想强度增加了错误的记忆率在两组。然而，明确的“关系处理”的指令，积极改善真正的记忆率只有在HC。最后，真和假记忆率与严重程度的混乱和阴性症状的SZ。这些结果表明，减少在SZ编码过程中的语义关系的处理可能源于无法实现显式的关系处理策略，而不是一个根本的赤字，在隐式激活和检索的词义从患者的语义词典。
Encoding semantic relationships between items on word lists (semantic processing) enhances true memories, but also increases memory distortions. Episodic memory impairments in schizophrenia (SZ) are strongly driven by failures to process semantic relations, but the exact nature of these relational semantic processing deficits are not well understood. Here, we used a false memory paradigm to investigate the impact of implicit and explicit semantic processing manipulations on episodic memory in SZ. Thirty SZ and 30 demographically matched healthy controls (HC) studied Deese/Roediger-McDermott (DRM) lists of semantically associated words. Half of the lists had strong implicit semantic associations and the remainder had low strength associations. Similarly, half of the lists were presented under “standard” instructions and the other half under explicit “relational processing” instructions. After study, participants performed recall and old/new recognition tests composed of targets, critical lures, and unrelated lures. HC exhibited higher true memories and better discriminability between true and false memory compared to SZ. High, versus low, associative strength increased false memory rates in both groups. However, explicit “relational processing” instructions positively improved true memory rates only in HC. Finally, true and false memory rates were associated with severity of disorganized and negative symptoms in SZ. These results suggest that reduced processing of semantic relationships during encoding in SZ may stem from an inability to implement explicit relational processing strategies rather than a fundamental deficit in the implicit activation and retrieval of word meanings from patients’ semantic lexicon.
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影响因子：
2.4
作者：
Brébion, G;David, AS;Pilowsky, LS
通讯作者：
Pilowsky, LS
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