Physical activity energy expenditure predicts progression toward the metabolic syndrome independently of aerobic fitness in middle-aged healthy Caucasians - The Medical Research Council Ely Study
Physical activity energy expenditure predicts progression toward the metabolic syndrome independently of aerobic fitness in middle-aged healthy Caucasians - The Medical Research Council Ely Study
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DOI：
10.2337/diacare.28.5.1195
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发表时间：
2005-05-01
期刊：
影响因子：
16.2
通讯作者：
Wareham, NJ
中科院分区：
文献类型：
--
作者：
Ekelund, U;Brage, S;Wareham, NJ
目的 - 在5.6年的时间里，对一组基于人群的基线时无代谢综合征的中年男性和女性（n = 605），研究体力活动能量消耗（PAEE）、有氧适能（VO₂max）、肥胖与代谢综合征进展之间的前瞻性关联。
研究设计与方法 - 通过针对能量消耗进行个体校准的心率来客观测量PAEE。通过次最大运动应激试验预测VO₂max。通过生物电阻抗评估脂肪量和去脂体重。通过将肥胖、高血压、高血糖、胰岛素抵抗、高甘油三酯血症以及高密度脂蛋白胆固醇的倒数水平的标准化值相加来计算代谢综合征评分，并将其表示为连续分布的结果。在调整性别、基线年龄、吸烟、社会经济状况、随访时间和基线表型后，使用广义线性模型来检验PAEE和VO₂max与代谢综合征评分之间的独立前瞻性关联。
结果 - PAEE可预测向代谢综合征的进展，且独立于基线代谢综合征、体脂、VO₂max以及其他混杂因素（标准化β = -0.00085，P = 0.046）。当从代谢综合征中排除肥胖成分时，这种关联更强（标准化β = -0.0011，P = 0.035）。在调整体力活动后，VO₂max不是代谢综合征的独立预测因子（标准化β = 0.00011，P = 0.93）。
结论 - PAEE可预测向代谢综合征的进展，且独立于有氧适能、肥胖以及其他混杂因素。这一发现强调了体力活动对预防代谢性疾病的重要性，即使有氧适能没有改善。
OBJECTIVE - To examine over a period of 5.6 years the prospective associations between physical activity energy expenditure (PAEE), aerobic fitness (VO2max), obesity, and the progression toward the metabolic syndrome in a population-based cohort of middle-aged men and women (n = 605) who were free of the metabolic syndrome at baseline.RESEARCH DESIGN AND METHODS - PAEE was measured objectively by individually calibrated heart rite against energy expenditure. VO2max was predicted from a submaximal exercise Stress test. Fat mass and fat-free mass were assessed by bio-impedance. A metabolic syndrome score was computed by summing the standardized values for obesity, hypertension, hyperglycemia, insulin resistance, hypetyriglyceridemia, and the inverse level of HDL-cholesterol and expressed as a continuously distributed outcome. Generalized linear models were used to examine the independent prospective associations between PAEE and Vo(2max) and the metabolic Syndrome score after adjusting for sex, baseline age, smoking, Socioeconomic status, follow-up time, and baseline phenotypes.RESULTS - PAEE predicted progression toward the metabolic syndrome, independent of baseline metabolic syndrome, body fat, VO2max, and other confounding factors (standardized beta = -0.00085, P = 0.046). This association was stronger when excluding the adiposity component from the metabolic syndrome (standardized beta = -0.0011, P = 0.035). Vo(2max) was not an independent predictor of the metabolic syndrome after adjusting for physical activity (standardized beta =0.00011, P = 0.93).CONCLUSIONS - PAEE predicts progression toward the metabolic syndrome independent of aerobic fitness, obesity, and other confounding factors. This finding underscores the importance of physical activity for metabolic disease prevention even when an improvement in aerobic fitness is absent.