Prevalence of Undiagnosed HIV Infection in Patients With Ocular Surface Squamous Neoplasia in a Tertiary Center in Karnataka, South India

Prevalence of Undiagnosed HIV Infection in Patients With Ocular Surface Squamous Neoplasia in a Tertiary Center in Karnataka, South India
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DOI：
10.1097/ico.0b013e3182479aed
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发表时间：
2012-11-01
期刊：
CORNEA
影响因子：
2.8
通讯作者：
Durgappa, Raviprakash
Durgappa, Raviprakash
中科院分区：
医学3区
文献类型：
--
作者：
Pradeep, Thanuja G.;Gangasagara, Suresh Babu;Durgappa, Raviprakash

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目的：为了评估未确诊和无症状的人类免疫缺陷病毒（HIV）感染的患病率与眼表鳞状细胞瘤（OSSN）在转诊医院在卡纳塔克邦，南India.Methods：一个连续系列的患者提出与OSSN在学术中心在2009年1月至2010年6月进行了评估。对25例OSSN患者进行详细的病史和体格检查。23名患者（88%）同意接受艾滋病毒血清学检测。其中，2人被排除在本研究，因为他们有着色性干皮病，一个已知的诱发因素OSSN.Results：在21例患者中，6例（29%）患者是HIV阳性。这些患者以前都没有接受过艾滋病毒检测。艾滋病毒阳性患者的中位发病年龄为36岁，而艾滋病毒阴性患者的中位发病年龄为54岁。HIV阳性患者的平均CD 4计数为133个细胞/mm（3），所有患者均开始接受抗逆转录病毒治疗。结论：结膜肿瘤可能是OSSN患者中HIV的主要和唯一明显表现，眼科医生需要注意这种关联。
Purpose: To evaluate the prevalence of undiagnosed and asymptomatic human immunodeficiency virus (HIV) infection in patients with ocular surface squamous neoplasia (OSSN) in a referral hospital in Karnataka, South India.Methods: A consecutive series of patients presenting with OSSN were evaluated in an academic center during January 2009 to June 2010. A detailed history was obtained and physical examination in 25 consecutive patients with OSSN was performed. Twenty-three patients (88%) agreed to undergo serological HIV testing. Of these, 2 were excluded from the current study because they had xeroderma pigmentosa, a known predisposing factor for OSSN.Results: Of the 21 patients, 6 (29%) patients were HIV positive. None of the patients had previous HIV testing. The median age of presentation among HIV-positive patients was 36 years, whereas it was 54 years among HIV-negative patients. The mean CD4 count in HIV-positive patients was 133 cells per mm(3), and all patients were started on antiretroviral treatment.Conclusions: The conjunctival tumor may be the primary and the only apparent manifestation of HIV in patients presenting with OSSN, and the ophthalmologist needs to be aware of this association.