MECHANISM OF COLLOIDAL PARTICLE UPTAKE INTO THE LYMPHATIC-SYSTEM - BASIC STUDY WITH PERCUTANEOUS LYMPHOGRAPHY
MECHANISM OF COLLOIDAL PARTICLE UPTAKE INTO THE LYMPHATIC-SYSTEM - BASIC STUDY WITH PERCUTANEOUS LYMPHOGRAPHY
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DOI：
10.1148/radiology.196.1.7784553
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发表时间：
1995-07-01
期刊：
影响因子：
19.7
通讯作者：
SCHMIDSCHONBEIN, GW
中科院分区：
文献类型：
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作者：
IKOMI, F;HANNA, GK;SCHMIDSCHONBEIN, GW
目的：研究细胞外(分散颗粒)和细胞内(吞噬颗粒)胶体颗粒从皮下组织到淋巴系统的转运情况。材料和方法：将LA11063(平均颗粒直径0.34微米)和ZY12149(平均颗粒直径0.06微米)分别注入兔后足背部皮肤。结果：在注射后24小时内，细胞外胶体流量明显大于细胞内胶体流量。随着按摩的进行，淋巴流率和胶体浓度显著增加。细胞外LA11063通量小于ZY12149通量，而细胞内LA11063通量大于ZY12149通量。结论：胶体进入淋巴管的转运依赖于颗粒大小。细胞外途径和细胞内途径都得到了利用。外部组织运动对通过这两个途径的粒子摄取速度有很大贡献。
PURPOSE: To examine the extracellular (dispersed particles) and intracellular (phagocytosed particles) colloidal particle transport from subcutaneous tissue into the lymphatic system.MATERIALS AND METHODS: Perfluorocarbon emulsions LA11063 (mean particle diameter, 0.34 mu m) and ZY12149 (mean particle diameter, 0.06 mu m) were individually injected into the dorsal skin of the hind foot of rabbits. Lymph flow rates and particle concentrations were determined in prenodal lymph fluid after injection, with and without massage of the skin over the injection site.RESULTS: In the first 24 hours after injection,extracellular colloid flux was substantially larger than intracellular flux. Lymph flow rates and colloid concentrations increased substantially with massage. Extracellular LA11063 flux was smaller than ZY12149 flux, whereas intracellular LA11063 flux exceeded ZY12149 flux.CONCLUSION: Transport of colloids into lymphatic vessels is dependent on particle size. Both extracellular and intracellular pathways are utilized. External tissue movement contributes substantially to the rate of particle uptake via both pathways.