Wilms tumor in five cousins.
Wilms tumor in five cousins.
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五个堂兄弟姐妹患有肾母细胞瘤。
DOI：
10.1542/peds.66.5.716
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发表时间：
1980
期刊：
影响因子：
8
通讯作者：
P. Gerald
中科院分区：
文献类型：
--
作者：
J. Cordero;F. Li;L. Holmes;P. Gerald
一个家族的五个堂兄弟姐妹发生了肾母细胞瘤。两名双侧肿瘤患者死亡，但三名单侧病变患者存活。所有患者均无相关的染色体缺陷、无虹膜、偏侧肥大或其他异常。该家族中的肾母细胞瘤的模式与肿瘤遗传的几种假定机制一致，并表明受影响家族中的亲属可能处于危险之中。
Wilms tumor developed in five cousins in a family. Two with bilateral tumors have died, but three with unilateral lesions have survived. None of the patients had associated chromosome defects, aniridia, hemihypertrophy, or other anomalies. The pattern of Wilms tumor in the family is consistent with several postulated mechanisms of inheritance of the neoplasm, and shows that relatives within affected families may be at risk.