Long-term reversal of hemispheric specialization for visual memory in a split-brain macaque.
Long-term reversal of hemispheric specialization for visual memory in a split-brain macaque.
复制标题
裂脑猕猴视觉记忆半球特化的长期逆转。
DOI：
10.1016/s0166-4328(99)00006-6
复制
发表时间：
1999
影响因子：
2.7
通讯作者：
Kavcic,V
中科院分区：
文献类型：
--
作者：
Doty,RW;Fei,R;Hu,S;Kavcic,V
三只分裂脑猕猴的反应准确性和眼球注视模式被用来评估每个大脑半球在连续视觉识别任务中的表现。这种动物通过眼睛盯着反应点来指示所显示的图像或面孔是新的还是老的。在一只动物身上，意外的扣带回损伤严重减少了对侧注视，并损害了受影响大脑半球的表现，证实了大脑半球与注视偏侧性之间的推断关系。最初，其他两种动物的大脑半球与人类面部和图像的准确性非常相似；但对于猕猴的面部，右侧大脑半球明显优于左侧大脑半球。与此类似，在一只同时使用两只眼睛/半球的受试动物中，注视主要集中在人类和猕猴面部的左半部(右半球对照)，而对于图像，眼睛注视主要集中在右半部。然而，在进一步的广泛训练后，左脑在所有材料上的表现都比右脑高得多，这种转变伴随着注视模式的逆转，并进一步证实了这一转变，有利于右半张脸的注视模式继续存在，图像也是如此。因此，从长期来看，眼球注视的模式和表现的准确性都表明，随着对任务的熟悉程度的增加，从右脑到左半球的优势转移。最初的上半球的表现实际上随着这种转变而减弱，提出了一个独特的令人费解的问题，即在没有前脑连合的情况下大脑半球的平衡。
Accuracy of response and pattern of ocular fixations in three split-brain macaques were used to evaluate performance of each hemisphere in a continuous visual recognition task. The animal indicated by ocular fixation upon response points whether a displayed image or face was ‘NEW’ or ‘OLD’. An inadvertent lesion of cingulate gyrus severely reduced contralateral fixations and impaired performance of the affected hemisphere in one animal, confirming the inferred relation between hemisphere and laterality of fixations. The hemispheres in the other two animals were initially remarkably similar in accuracy with human faces and with images; but the right hemisphere was significantly superior to the left for macaque faces. Parallel to this, in the one animal tested while simultaneously using both eyes/hemispheres, fixations were made primarily on the left half of human and macaque faces (right hemispheric control), whereas for images the ocular fixations were predominantly focussed on the right half. However, after further, extensive training the left hemisphere performed with significantly greater accuracy than the right on all material and this shift was accompanied and further corroborated by a reversal of the fixational pattern to favor the right half of faces, as continued to be the case with images. Thus, over the long term both the pattern of ocular fixations and the accuracy of performance demonstrate a migration from right to left hemispheric dominance as familiarity with the task increased. Performance of the initially superior hemisphere actually diminished with this shift, presenting a uniquely puzzling question of hemispheric balance in the absence of the forebrain commissures.