Cytotoxic Indolyl Diketopiperazines from the Aspergillus sp. GZWMJZ-258, Endophytic with the Medicinal and Edible Plant Garcinia multiflora
Cytotoxic Indolyl Diketopiperazines from the Aspergillus sp. GZWMJZ-258, Endophytic with the Medicinal and Edible Plant Garcinia multiflora
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来自曲霉属的细胞毒性吲哚基二酮哌嗪。
DOI：
10.1021/acs.jafc.9b04254
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发表时间：
2019-09-25
影响因子：
6.1
通讯作者：
Zhu, Weiming
中科院分区：
文献类型：
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作者：
He, Wenwen;Xu, Yanchao;Zhu, Weiming
从栀子属内生真菌Aspergillus sp. GZWMJZ-258的固体培养物中分离到两个新的吲哚基二酮哌嗪类化合物gartryprostatins A和B(1和2)，具有一个不常见的2,3-呋喃融合pyrano[2,3-g]pyrrolo[1 ',2': 4',5'] pyrrolo[2,3- B]吲哚核，以及一个新的天然化合物gartryprostatin C， 3。化合物1-3的结构通过核磁共振、质谱、氨基酸的Marfey分析和化学计算确定。化合物1-3对人FLT3-ITD突变型AML细胞株MV4-11有选择性抑制作用，IC50值分别为7.2、10.0和0.22 μ M。
Two new indolyl diketopiperazines, gartryprostatins A and B (1 and 2), with an unusual 2,3-furan-fused pyrano[2,3-g]pyrrolo[1 '',2 '':4',5']pyrazino[1',2':1,5]pyrrolo[2,3-b]indole nucleus, along with a new naturally occurring compound (gartryprostatin C, 3) were isolated from the solid culture of Aspergillus sp. GZWMJZ-258, an endophyte from Garcinia multiflora (Guttiferae). The structures of compounds 1-3 were determined by nuclear magnetic resonance, mass spectrometry, Marfey's analysis of amino acids, and chemical calculation. Compounds 1-3 displayed selective inhibition on human FLT3-ITD mutant AML cell line, MV4-11, with IC50 values of 7.2, 10.0, and 0.22 mu M, respectively.