Body composition, visceral fat, leptin, and insulin resistance in Asian Indian men
Body composition, visceral fat, leptin, and insulin resistance in Asian Indian men
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DOI：
10.1210/jc.84.1.137
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发表时间：
1999-01-01
影响因子：
5.8
通讯作者：
Lebovitz, HE
中科院分区：
文献类型：
--
作者：
Banerji, MA;Faridi, N;Lebovitz, HE
尽管没有传统的危险因素，但在城市和移民的亚洲印度人中，2型糖尿病和冠状动脉疾病的发病率很高。有证据表明，亚洲印度人比高加索人更高胰岛素血症，高胰岛素血症可能在这些疾病的发展中很重要。为了检验胰岛素作用是否与总体或局部肥胖有关，并探讨血浆瘦素和脂质的潜在作用，我们在20名健康的亚洲印度男性志愿者中，通过正葡萄糖胰岛素钳夹、计算机轴向断层扫描测量了胰岛素介导的葡萄糖处理、脂肪分布和肌肉体积，以及空腹血清瘦素和脂质水平平均体重指数为24.5 +/- 2.5 kg/m2的人，其体脂百分比异常高（35 +/- 7%）。大部分脂肪是皮下脂肪，16%是内脏（腹腔内）脂肪组织。这些非肥胖男性中的大多数（66%）是胰岛素抵抗。平均空腹血清瘦素水平为7.6 +/- 3.3 ng/mL。胰岛素作用与内脏脂肪组织呈负相关，而与总脂肪组织或腹部皮下脂肪组织无关。相反，瘦素水平与皮下脂肪和总脂肪（非内脏）相关。血清甘油三酯和高密度脂蛋白胆固醇水平呈负相关，彼此和直接相关的胰岛素抵抗和内脏（而不是皮下）脂肪。增加内脏脂肪在亚洲印度人与增加全身性肥胖，这是不明显的，从他们的非肥胖体重指数。内脏脂肪增加与血脂异常和胰岛素抵抗频率增加有关，可能是亚洲印度人糖尿病和心血管疾病患病率增加的原因。
There is a high prevalence of type 2 diabetes mellitus and coronary artery disease among urban and migrant Asian Indians despite the absence of traditional risk factors. Evidence exists that Asian Indians are more hyperinsulinemic than Caucasians and that hyperinsulinemia may be important in the development of these diseases. To test whether insulin action was related to total or regional adiposity and to explore the potential role of plasma leptin and lipids, we measured insulin-mediated glucose disposal by the euglycemic insulin clamp, adipose distribution and muscle Volume using computed axial tomography, and fasting serum leptin and lipid levels in 20 healthy Asian Indian male Volunteers (age, 36 +/- 10 yr).A mean body mass index of 24.5 +/- 2.5 kg/m(2) was associated with an unusually high percentage of body fat (35 +/- 7%). The majority of the fat was sc, and 16% was visceral (intraabdominal) adipose tissue. The majority (66%) of these nonobese men were insulin resistant. The mean fasting serum leptin level was 7.6 +/- 3.3 ng/mL.Insulin action was inversely correlated with visceral adipose tissue, not total or abdominal sc adipose tissue. In contrast, leptin levels correlated with sc and total (not visceral) adipose tissue. Serum triglyceride and high density lipoprotein cholesterol levels were inversely correlated with each other and were directly related to insulin resistance and visceral (not subcutaneous) fat.Increased Visceral fat in Asian Indians is associated with increased generalized obesity, which is not apparent from their nonobese body mass index. Increased visceral fat is related to dyslipidemia and increased frequency of insulin resistance and may account for the increased prevalence of diabetes mellitus and cardiovascular disease in Asian Indians.