Requirement of essential fatty acid for mammary tumorigenesis in the rat.
Requirement of essential fatty acid for mammary tumorigenesis in the rat.
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发表时间：
1985-05
期刊：
影响因子：
11.2
通讯作者：
C. Ip;C. A. Carter;M. Ip
中科院分区：
文献类型：
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作者：
C. Ip;C. A. Carter;M. Ip
为了确定二甲基苯并蒽诱导的乳腺肿瘤发生对必需脂肪酸的需求，给大鼠喂食含有不同水平亚油酸酯的饲料：0.5、1.1、1.7、2.2、3.5、4.4、8.5或11.5%。每种饮食含有20%重量的脂肪，添加不同量的椰子油和玉米油以达到所需的亚油酸水平。乳腺肿瘤发生对亚油酸摄入量非常敏感，在0.5%至4.4%的膳食亚油酸摄入量范围内比例增加。回归分析表明，在4.4%处出现断点，超过该断点，线性关系非常差，表明可能出现平台期。根据上限和下限范围内回归线的交点，估计引发最大致瘤反应所需的亚油酸酯水平约为4%。肿瘤产量的差异不能与前列腺素E浓度的变化保持在类似的饮食正常动物的乳腺脂肪垫，这表明亚油酸酯可能会通过一些其他的机制来刺激乳腺肿瘤的发生。
In an attempt to determine the requirement of essential fatty acid for dimethylbenz(a)anthracene-induced mammary tumorigenesis, rats were fed diets containing different levels of linoleate: 0.5, 1.1, 1.7, 2.2, 3.5, 4.4, 8.5, or 11.5%. Each diet contained 20% of fat by weight, with varying amounts of coconut oil and corn oil added to achieve the desired levels of linoleate. Mammary tumorigenesis was very sensitive to linoleate intake and increased proportionately in the range of 0.5 to 4.4% of dietary linoleate. Regression analysis indicated that a breakpoint occurred at 4.4%, beyond which there was a very poor linear relationship, suggesting the possibility of a plateau. From the intersection of the regression lines in both the upper and lower ranges, the level of linoleate required to elicit the maximal tumorigenic response was estimated to be around 4%. The differences in tumor yield could not be correlated with changes in prostaglandin E concentration in the mammary fat pads of normal animals maintained on similar diets, suggesting that linoleate may act by some other mechanism to stimulate mammary tumorigenesis.