Effects of sample geometry and electrode configuration on measured electrical resistivity of skeletal muscle
Effects of sample geometry and electrode configuration on measured electrical resistivity of skeletal muscle
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DOI：
10.1109/10.821749
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发表时间：
2000-02-01
影响因子：
4.6
通讯作者：
Peura, R
中科院分区：
文献类型：
--
作者：
Kun, S;Peura, R
在过去的40年里，来自不同科学背景的研究人员一直在使用拉什方程来分析他们的电生理研究结果。缺乏了解的约束条件和域中，这些方程是有效的，往往会导致在这种情况下，它是具有挑战性的评估和比较所获得的结果由不同的Investigator.In本文中，我们重新分析了拉什的方程推导的条件，并使用数学建模，计算机模拟和体外测量，我们划定了他们的适当的应用领域。我们的研究表明，样本几何形状和测试电极配置都会影响测量的组织电导率：1）只有当样品的尺寸>50个电极间间隔距离（IESD）并且厚度>2.5个IESD时，样品才可以被认为是半无限的，2）较小的样品尺寸增加了横向测量的电阻率，3）薄于2.5个IESD的半无限样品，4）当表面-点电极纵向排列时，随着IESD/组织厚度比的减小，测量的电阻率增加。我们的结论是，在大多数实验情况下，有必要使用建模技术将电极配置/样品几何形状的影响与测量的组织电阻率解耦。
Over the past 40 years, researchers from a variety of scientific backgrounds have been using Rush's equations to analyze results of their electrophysiological studies. A lack of understanding of the constraints and the domain in which these equations are valid, often results in situations in which it is challenging to evaluate and compare results obtained by different investigators.In this paper, we reanalyzed the conditions for which Rush's equations were derived, and using mathematical modeling, computer simulation and in vitro measurements, we delineated areas of their appropriate application. Our studies showed that both sample geometry and test electrode configuration affect the measured tissue electrical resistivities: 1) The sample can be considered semi-infinite only if its dimensions are >50 inter-electrode separation distances (IESD), and thickness >2.5 IESD, 2) smaller sample sizes increase the transversally measured resistivity, 3) semi-infinite samples thinner than 2.5 IESD, and samples tested with needle electrodes demonstrate reduced anisotropy, and 4) when surface-spot electrodes are longitudinally aligned, as the IESD/tissue thickness ratio decreases, the measured resistivity increases.Our conclusion is that in most experimental situations, it is necessary to use modeling techniques to decouple the electrode configuration/sample geometry influence from the measured tissue resistivity.