Tumor microenvironment responsive hollow mesoporous Co9S8@MnO2-ICG/DOX intelligent nanoplatform for synergistically enhanced tumor multimodal therapy
Tumor microenvironment responsive hollow mesoporous Co9S8@MnO2-ICG/DOX intelligent nanoplatform for synergistically enhanced tumor multimodal therapy
复制标题
肿瘤微环境响应型中空介孔Co9S8@MnO2-ICG/DOX智能纳米平台协同增强肿瘤多模式治疗
DOI：
10.1016/j.biomaterials.2020.120346
复制
发表时间：
2020-12-01
期刊：
影响因子：
14
通讯作者：
Zeng, Songjun
中科院分区：
文献类型：
--
作者：
Huang, Junqing;Huang, Yao;Zeng, Songjun
结合肿瘤微环境（TME）响应的双T-1/T-2磁共振（MR）成像和协同自增强光热/光动力/化学治疗的多功能纳米平台的开发对于肿瘤治疗诊断具有重要意义，这仍然是一个巨大的挑战。本文设计了一种新型中空介孔双壳层Co9S8@MnO2纳米平台，负载吲哚菁绿色分子（ICG）和化疗药物阿霉素（DOX），用于TME响应性双T-1/T-2增强MR成像和协同增强抗肿瘤治疗。所设计的具有MnO 2壳的纳米平台可以作为TME响应的氧气自给生产者，以减轻肿瘤缺氧，同时提高光动力治疗（PDT）效率。此外，TME诱导的MnO 2溶解和Co 9 S8壳的近红外（NIR）触发的光热性质可以进一步促进肿瘤靶向的DOX释放，导致协同改善的抗肿瘤功效。并实现了T1/T2双信号同步增强，对肿瘤的诊断具有较高的特异性。体内和体外实验结果证实，所设计的TME触发纳米平台与协同联合治疗具有良好的生物相容性，并且比单药治疗具有上级抑制肿瘤生长的作用。本研究为设计智能TME激活的纳米平台提供了机会，用于高度特异性的肿瘤MR成像和协同自增强肿瘤治疗。
The development of multifunctional nanoplatform with combination of tumor microenvironment (TME)-responsive dual T-1/T-2 magnetic resonance (MR) imaging and synergistically self-enhanced photothermal/photodynamic/chemo-therapy is of significant importance for tumor theranostic, which still remains a great challenge. Herein, a novel hollow mesoporous double-shell Co9S8@MnO2 nanoplatform loaded with photodynamic agent of indocyanine green molecules (ICG) and chemotherapy drug of doxorubicin (DOX) was designed for TME responsive dual T-1/T-2 enhanced MR imaging and synergistically enhanced anti-tumor therapy. The designed nanoplatform with MnO2 shell can act as a TME-responsive oxygen self-supplied producer to alleviate tumor hypoxia and simultaneously improve photodynamic therapy (PDT) efficiency. Moreover, the TME-induced MnO2 dissolving and near-infrared (NIR) triggered photothermal nature from Co9S8 shell can further promote the tumor-targeted DOX release, leading to the synergistically improved anti-tumor efficacy. And the simultaneous enhancement in dual T-1/T-2 MR signal was achieved for highly specific tumor diagnosis. The in vivo and in vitro results confirmed that the designed TME-triggered nanoplatform with synergistic combination therapy presented good biocompatibility, and superior inhibition of tumor growth than monotherapy. This study provides the opportunities of designing intelligent TME-activated nanoplatform for highly specific tumor MR imaging and collaborative self-enhanced tumor therapy.