Extracellular vesicles in inflammation: Focus on the microRNA cargo of EVs in modulation of liver diseases.
Extracellular vesicles in inflammation: Focus on the microRNA cargo of EVs in modulation of liver diseases.
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DOI：
10.1002/jlb.3mir0321-156r
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发表时间：
2022-01
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
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作者：
细胞外囊泡 (EV) 是细胞在正常和病理条件下释放的异质纳米颗粒。 EV 货物由 DNA、蛋白质、脂质货物、代谢物、mRNA 和非编码 RNA 组成，可以通过改变炎症反应来调节免疫系统。 EV 相关 miRNA 有助于酒精性肝病、非酒精性肝病、病毒性肝炎、对乙酰氨基酚诱导的肝损伤、纤维化和肝细胞癌的病理学。在肝脏疾病中，EV通过其货物与肝脏内以及肝脏与其他器官之间的不同细胞类型进行通信，从而改变炎症反应。本文综述了 EV 及其相关 miRNA 在不同肝脏疾病细胞间通讯中的作用以及作为潜在生物标志物和治疗靶点的作用。
Extracellular vesicles (EVs) are heterogeneous nanometer-ranged particles that are released by cells under both normal and pathological conditions. EV cargo comprises of DNA, protein, lipids cargo, metabolites, mRNA, and non-coding RNA that can modulate the immune system by altering inflammatory response. EV associated miRNAs contribute to the pathobiology of alcoholic liver disease, non-alcoholic liver disease, viral hepatitis, acetaminophen-induced liver injury, fibrosis, and hepatocellular carcinoma. In context of liver diseases, EVs, via their cargo, alter the inflammatory response by communicating with different cell types within the liver and between liver and other organs. Here, the role of EVs and its associated miRNA in inter-cellular communication in different liver disease and as a potential biomarker and therapeutic target is reviewed.