Immune thrombocytopenic purpura
Immune thrombocytopenic purpura
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DOI：
10.1007/s12098-008-0137-z
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发表时间：
2008-07-01
影响因子：
4.3
通讯作者：
Bhatia, B. D.
中科院分区：
文献类型：
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作者：
Gupta, V.;Tilak, V.;Bhatia, B. D.
免疫性血小板减少性紫癜（ITP）是最常见的原因突发性血小板减少在一个健康的孩子。这种情况通常发生在病毒感染之前。血液学参数除血小板计数低外基本正常。除特殊情况外，骨髓检查不是常规指征。由于本病为良性，多数病例预后良好，故对药物治疗的利弊进行了讨论。包括低剂量和高剂量类固醇、静脉注射免疫球蛋白和抗D在内的各种治疗方案已与其他治疗方式和脾切除术的作用进行了详细讨论。目前在慢性病例中使用利妥昔单抗和其他药物刺激血小板产生的治疗选择也包括在讨论中。
Immune thrombocytopenic purpura (ITP) is the commonest cause of sudden onset thrombocytopenia in a healthy child. The condition is frequently preceded by a viral infection. The hematological parameters are essentially normal except a low platelet count. Bone marrow examination is not routinely indicated except in specific situations. The pros and cons of drug treatment have been discussed as the disease is benign with excellent prognosis in majority of the cases. The various treatment options including low and high dose steroids, intravenous immunoglubulins and anti D have been discussed at length with other modalities of treatment and role of splenctomy. Current therapeutic options with rituximab and other drugs for stimulating platelet production in chronic cases have also been included in discussion.