p-Terphenyl and Diterpenoid Metabolites from Endophytic Aspergillus sp YXf3
p-Terphenyl and Diterpenoid Metabolites from Endophytic Aspergillus sp YXf3
复制标题
内生曲霉 YXf3 中的对三联苯和二萜代谢物
DOI：
10.1021/np200321s
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发表时间：
2012-01-01
影响因子：
5.1
通讯作者：
Ge, Hui Ming
中科院分区：
文献类型：
--
作者：
Guo, Zhi Kai;Yan, Tong;Ge, Hui Ming
从植物内生真菌曲霉发酵液中分离得到6个新的对三苯基化合物，分别命名为4“-脱氧-3-羟基三苯基(1)、4”-脱氧-5‘-脱甲基三苯基(2)、5’-脱甲基三苯基(3)、4“-脱氧假丝酵母素A(4)、4，5-二甲氧基假丝酵母A(5)和萜内酯(6)，4个新的二萜类化合物(曲霉A(12)和曲霉B(13))，裂环烷(曲霉类C(14))和异丙基松烷(曲霉D(15)型骨架)，以及5个已知的对三苯基化合物(7-11)。通过详细的波谱分析和与文献报道的核磁共振数据的比较，确定了它们的结构。化合物4、6、7和9具有中等的神经氨酸酶抑制活性，IC50值在4.34~9.17微米之间。
Six new p-terphenyl derivatives, named 4"-deoxy-3-hydroxyterphenyllin (1), 4"-deoxy-5'-desmethylterphenyllin (2), 5'-desmethylterphenyllin (3), 4"-deoxycandidusin A (4), 4,5-dimethoxycandidusin A (5), and terphenolide (6), four new diterpenoids with norcleistanthane (aspergiloid A (12) and aspergiloid B (13)), cleistanthane (aspergiloid C (14)), and isopimarane (aspergiloid D (15)) type skeletons, and five known p-terphenyl compounds (7-11) were isolated from the fermentation broth of the plant endophytic fungus Aspergillus sp. Their structures were elucidated on the basis of detailed spectroscopic analysis and by comparison of their NMR data with those reported in the literature. Compounds 4, 6, 7, and 9 displayed moderate neuraminidase inhibitory activity with IC50 values ranging from 4.34 to 9.17 mu M.