Structure of the globular region of the prion protein Ure2 from the yeast Saccharomyces cerevisiae
Structure of the globular region of the prion protein Ure2 from the yeast Saccharomyces cerevisiae
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DOI：
10.1016/s0969-2126(00)00553-0
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发表时间：
2001-01-10
期刊：
影响因子：
5.7
通讯作者：
Morera, S
中科院分区：
文献类型：
--
作者：
Bousset, L;Belrhali, H;Morera, S
背景：酵母S.酿酒酵母的感染是由于蛋白质Ure2的可传播形式的繁殖。Ure2p的感染性被认为起源于朊病毒蛋白正常形式的构象变化。这种构象变化产生一种形式的Ure2p，其组装成淀粉样纤维。因此，朊病毒蛋白质如Ure2p的三维结构的知识应该有助于理解与许多神经退行性疾病相关的淀粉样蛋白形成的机制。
Background: The [URE3] non-Mendelian element of the yeast S. cerevisiae is due to the propagation of a transmissible form of the protein Ure2. The infectivity of Ure2p is thought to originate from a conformational change of the normal form of the prion protein. This conformational change generates a form of Ure2p that assembles into amyloid fibrils. Hence, knowledge of the three-dimensional structure of prion proteins such as Ure2p should help in understanding the mechanism of amyloid formation associated with a number of neurodegenerative diseases.