Increased risk of lung cancer associated with occupational exposure to benzidine and/or beta-naphthylamine.
Increased risk of lung cancer associated with occupational exposure to benzidine and/or beta-naphthylamine.
复制标题
职业接触联苯胺和/或 β-萘胺会增加患肺癌的风险。
DOI：
10.1007/s00420-014-0974-1
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发表时间：
2015
影响因子：
3
通讯作者：
Kurumatani N.
中科院分区：
文献类型：
--
作者：
Tomioka K;Obayashi K;Saeki K;Okamoto N;Kurumatani N.
目的评价联苯胺（BZ）和-萘胺（BNA）与非泌尿系癌症的相关风险，进行了一项历史队列研究。方法对1953 ~ 2011年同一工厂暴露于BZ/BNA的224名男性工人进行随访。为了估计BZ/BNA的暴露剂量，暴露持续时间（DOE）定义为1953年至1972年的工作时间，即该工厂生产和使用BZ和BNA的时间。根据DOE的中位数将受试者分为长期组和短期组。以国家和地区发病率为参考，计算癌症特异性标准化发病率（SIRs）。通过问卷调查和其他途径获得吸烟史。采用Cox比例风险模型评估肺癌（LC）或膀胱癌（BC）发病率与DOE的关系。结果生命状态随访成功216例（96.4%）。随访时间平均为44.0 （SD 10.7）年。所有癌症（81例，SIR = 1.58, 95% CI 1.26-1.98）、LC（18例，SIR = 2.58, 95% CI 1.53-4.07）和BC（7例，SIR = 4.70, 95% CI 1.89-9.67）的SIR均增加。在首次接触后20年>的工人中，长DOE组的LC SIR有统计学升高（15例，SIR = 3.34, 95% CI 1.87-5.51）。在调整吸烟、氯甲基醚暴露和首次暴露年龄后，与短时间DOE组相比，长时间DOE组的危险比（HR = 3.02, 95% CI 0.84-10.93,p= 0.091）具有边际显著性。DOE不影响BC的发病率。结论本研究证实除了BC外，BZ/BNA具有LC的高危性，提示BZ/BNA有可能引起LC。
PurposeTo evaluate non-urological cancer risks associated with benzidine (BZ) and beta-naphthylamine (BNA), a historical cohort study was undertaken.MethodsA total of 224 male workers exposed to BZ/BNA from a single factory were followed from 1953 to 2011. To estimate BZ/BNA exposure dose, duration of exposure (DOE) was defined as duration of employment between 1953 and 1972, the period when BZ and BNA were produced and used at this factory. Subjects were dichotomized (into long- and short-term groups) based on the median of DOE. Cancer-specific standardized incidence ratios (SIRs) were calculated using national and regional incidence rates as reference. Smoking history was obtained through questionnaires and other sources. Association between lung cancer (LC) or bladder cancer (BC) incidence and DOE was assessed using Cox’s proportional hazards model.ResultsVital status follow-up was successful for 216 (96.4 %). Follow-up duration averaged 44.0 (SD 10.7) years. Increased SIRs based on national rates were found for all cancers (81 cases, SIR = 1.58, 95 % CI 1.26–1.98), LC (18 cases, SIR = 2.58, 95 % CI 1.53–4.07), and BC (7 cases, SIR = 4.70, 95 % CI 1.89–9.67). Among workers with >20 years after first exposure, the SIR for LC was statistically elevated in the long DOE group (15 cases, SIR = 3.34, 95 % CI 1.87–5.51). After adjustment for smoking, exposure to bis(chloromethyl) ether, and age at first exposure, a marginally significant hazard ratio (HR) was observed for the long DOE group (adjusted HR = 3.02, 95 % CI 0.84–10.93,p= 0.091), compared to the short DOE group. DOE did not affect BC incidence.ConclusionsThis study confirms the high risk of LC besides BC, suggesting that BZ/BNA have the potential to cause LC.