The diagnostics of colorectal cancer.
The diagnostics of colorectal cancer.
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DOI：
10.5114/wo.2013.39995
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Zwierz K
中科院分区：
文献类型：
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作者：
Swiderska M;Choromańska B;Dąbrowska E;Konarzewska-Duchnowska E;Choromańska K;Szczurko G;Myśliwiec P;Dadan J;Ladny JR;Zwierz K
结直肠癌(CRC)是人类最常见的恶性肿瘤之一。据估计，全世界每年有超过100万的新病例发生。大约每三个罹患CRC的人中就有一个死于这种疾病。此外，与欠发达国家相比，《儿童权利公约》经常影响工业化国家的居民。结肠癌的几个标志物，包括CEA、CA-19-9、TPS、TAG-72和溶酶体水解酶已经被鉴定出来，现在正在被常规的临床实践所采用。这些标记物的升高往往是复发或转移的第一个信号，这对预测和预测结直肠癌患者的临床预后很有帮助。体液中溶酶体外糖苷酶活性的测定可能为提高结直肠癌的诊断水平带来一些希望。然而，必须记住的是，目前结直肠癌最有效的诊断方法是内窥镜检查。
Colorectal cancer (CRC) is one of the most frequent human malignant neoplasms. CRC has an estimated incidence of more than 1,000,000 new cases annually worldwide. Approximately one out of three people who develop CRC dies from the disease. Furthermore, CRC often affects inhabitants of industrialized countries in comparison to less developed countries. Several markers of colon cancer, including CEA, CA-19-9, TPS, TAG-72 and lysosomal hydrolases, have been identified and are now being adopted in routine clinical practice. Increased values of these markers are often the first signal of recurrence or metastases, which is useful in prediction and prognosis of clinical outcome of patients with CRC. Determination of the activity of lysosomal exoglycosidases in body fluids may bring some hope of improving diagnosis of colorectal cancer. However, it has to be remembered that currently the most effective diagnostic method of CRC is endoscopy.