HOAc-Assisted Synthesis of 2,3-Disubstituted Quinolines from Arylamine and Aliphatic Aldehyde in Water
HOAc-Assisted Synthesis of 2,3-Disubstituted Quinolines from Arylamine and Aliphatic Aldehyde in Water
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HOAc辅助芳胺和脂肪醛在水中合成2,3-二取代喹啉
DOI：
10.1002/slct.201901686
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发表时间：
2019
期刊：
影响因子：
2.1
通讯作者：
Tang Ya-Lin
中科院分区：
文献类型：
--
作者：
Zhang Jing-Tao;Wang Li-Xia;Xiang Jun-Feng;Cui Jie;Hu Ben-Quan;Yang Luo;Tang Ya-Lin
在这里，我们报告了一个HOAc辅助的协议，以合成2，3-二取代喹啉在水中，从可用的起始原料芳胺和脂肪醛。芳胺底物具有较好的普适性。而苯乙醛导致2，3-二取代喹啉产物的产率非常低，伴随着涉及C-C裂解的单取代喹啉。
Here we report that a HOAc‐assisted protocol to synthesize 2,3‐disubstituted quinolines in water, from the available starting materials arylamine and aliphatic aldehyde. The arylamine substrates showed a good universality. While the phenylacetaldehyde led to a 2,3‐disubstituted quinoline product in a very low yield, accompanied by the mono‐substituted quinoline involving C−C cleavage.