Within-subregion relationship between bone marrow lesions and subsequent cartilage loss in knee osteoarthritis.
Within-subregion relationship between bone marrow lesions and subsequent cartilage loss in knee osteoarthritis.
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DOI：
10.1002/acr.20068
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发表时间：
2010-02
影响因子：
4.7
通讯作者：
Sharma, Leena
中科院分区：
文献类型：
--
作者：
Kothari, Ami;Guermazi, Ali;Chmiel, Joan S.;Dunlop, Dorothy;Song, Jing;Almagor, Orit;Marshall, Meredith;Cahue, September;Prasad, Pottumarthi;Sharma, Leena
骨髓病变被认为会增加膝关节骨关节炎（OA）进展的风险。它们的影响是否是局部的，以及是否可以用同一亚区伴随存在的其他类型的骨病变来解释尚不清楚。我们评估了无软骨病变亚区的骨病变频率和无骨病变亚区的软骨病变频率，并在基线时调整其他类型的骨病变后，研究了亚区内骨髓病变/随后软骨损失的关系。膝关节OA患者在基线和两年后进行MRI检查。对胫股亚区的骨髓病变、骨囊肿、骨磨损和软骨完整性进行评分。使用GEE的Logistic回归来解释膝关节内多个亚区之间的相关性，以估计与骨髓病变相关的软骨丢失的OR，调整了同一亚区的年龄、性别、BMI和骨磨损和囊肿。分析177个膝关节中的1953个亚区，90%的亚区在基线时没有骨病变。只有0-3%的无软骨病变的亚区在同一亚区有骨病变;相反，5-33%的无骨病变的亚区有软骨病变。基线时骨髓病变与相同亚区的2年软骨丢失相关，校正基线时其他类型的骨病变（校正OR 3.74，95% CI 1.59，8.82）。在膝关节OA患者中，骨髓病变在疾病早期阶段很少见，但在考虑到同一亚区存在其他类型的骨病变后，可预测亚区软骨丢失。
Bone marrow lesions are believed to increase risk of knee osteoarthritis (OA) progression. Whether their effect is local and whether it can be explained by other types of bone lesions concomitantly present in the same subregion is unclear. We evaluated bone lesion frequency in subregions without cartilage lesions and cartilage lesion frequency in subregions without bone lesions and investigated the within-subregion bone marrow lesion/subsequent cartilage loss relationship after adjusting for other types of bone lesions at baseline. Individuals with knee OA had MRI at baseline and two years later. Bone marrow lesions, bone cysts, bone attrition, and cartilage integrity were scored within tibiofemoral subregions. Logistic regression with GEE to account for correlation among multiple subregions within a knee was used to estimate ORs for cartilage loss associated with bone marrow lesions adjusting for age, gender, BMI, and bone attrition and cysts in the same subregion. Analyzing 1953 subregions among 177 knees, 90% of subregions had no bone lesion at baseline. Only 0–3% of subregions without cartilage lesions had bone lesions in the same subregion; in contrast, 5–33% of subregions without bone lesions had cartilage lesions. Bone marrow lesions at baseline were associated with 2 year cartilage loss in the same subregion, adjusting for other types of bone lesions at baseline (adjusted OR 3.74, 95% CI 1.59, 8.82). In persons with knee OA, bone marrow lesions were rare at early disease stages but predicted subregional cartilage loss after accounting for the presence of other types of bone lesions in the same subregion.
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影响因子：
--
作者：
Hunter, David J.;Zhang, Yuqing;Felson, David T.
通讯作者：
Felson, David T.
影响因子：
19.7
作者：
Kijowski, R;Stanton, P;De Smet, A
通讯作者：
De Smet, A
影响因子：
7
作者：
Peterfy, CG;Guermazi, A;Genant, HK
通讯作者：
Genant, HK
DOI：
10.7326/0003-4819-139-5_part_1-200309020-00008
发表时间：
2003-09-02
影响因子：
39.2
作者：
Felson, DT;McLaughlin, S;Gale, D
通讯作者：
Gale, D
影响因子：
27.4
作者：
Raynauld, J-P;Martel-Pelletier, J.;Pelletier, J-P
通讯作者：
Pelletier, J-P