Layer-by-Layer polyelectrolyte assemblies for encapsulation and release of active compounds
Layer-by-Layer polyelectrolyte assemblies for encapsulation and release of active compounds
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DOI：
10.1016/j.cis.2017.04.009
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发表时间：
2017-11-01
影响因子：
15.6
通讯作者：
Rubio, Ramon G.
中科院分区：
文献类型：
--
作者：
Guzman, Eduardo;Mateos-Maroto, Ana;Rubio, Ramon G.
Soft assemblies obtained following the Layer-by-Layer (LbL) approach are accounted among the most interesting systems for designing biomaterials and drug delivery platforms. This is due to the extraordinary versatility and flexibility offered by the LbL method, allowing for the fabrication of supramolecular multifunctional materials using a wide range of building blocks through different types of interactions (electrostatic, hydrogen bonds, acid base or coordination interactions, or even covalent bonds). This provides the bases for the building of materials with different sizes, shapes, compositions and morphologies, gathering important possibilities for tuning and controlling the physico-chemical properties of the assembled materials with precision in the nanometer scale, and consequently creating important perspective for the application of these multifunctional materials as cargo systems in many areas of technological interest. This review studies different physico chemical aspects associated with the assembly of supramolecular materials by the LbL method, paying special attention to the description of these aspects playing a central role in the application of these materials as cargo platforms for encapsulation and release of active compounds.
