Genetic disruptions of Drosophila Pavlovian learning leave extinction learning intact.
Genetic disruptions of Drosophila Pavlovian learning leave extinction learning intact.
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DOI：
10.1111/j.1601-183x.2009.00548.x
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发表时间：
2010-03-01
期刊：
影响因子：
--
通讯作者：
Dubnau J
中科院分区：
文献类型：
--
作者：
Qin H;Dubnau J
Individuals that experience traumatic events may develop persistent post-traumatic stress disorder (PTSD). Patients with this disorder are commonly treated with exposure therapy, which has had limited long-term success. In experimental neurobiology, fear extinction is a model for exposure therapy. In this behavioral paradigm, animals are repeatedly exposed in a safe environment to the fearful stimulus, which leads to greatly reduced fear. Studying animal models of extinction already has lead to better therapeutic strategies and development of new candidate drugs. Lack of a powerful genetic model of extinction, however, has limited progress in identifying underlying molecular and genetic factors. In this study, we established a robust behavioral paradigm to study the short term effect (acquisition) of extinction in Drosophila melanogaster. We focused on the extinction of olfactory aversive one-day memory with a task that has been the main workhorse for genetics of memory in flies. Using this paradigm, we demonstrate that extinction can inhibit each of two genetically distinct forms of consolidated memory. We then used a series of single-gene mutants with known impact on associative learning, to examine effects on extinction. We find that extinction is intact in each of these mutants, suggesting that extinction learning relies on different molecular mechanisms than does Pavlovian learning.
