Effects of chromium malate on glycometabolism, glycometabolism-related enzyme levels and lipid metabolism in type 2 diabetic rats: A dose-response and curative effects study.
Effects of chromium malate on glycometabolism, glycometabolism-related enzyme levels and lipid metabolism in type 2 diabetic rats: A dose-response and curative effects study.
复制标题
苹果酸铬对2型糖尿病大鼠糖代谢、糖代谢相关酶水平和脂质代谢的影响：剂量反应和疗效研究。
DOI：
10.1111/jdi.12350
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发表时间：
2015-07
影响因子：
3.2
通讯作者：
Wu X
中科院分区：
文献类型：
--
作者：
Feng W;Mao G;Li Q;Wang W;Chen Y;Zhao T;Li F;Zou Y;Wu H;Yang L;Wu X
本研究旨在评估苹果酸铬对2型糖尿病大鼠糖代谢、糖代谢相关酶水平和脂质代谢的影响，以及剂量反应和疗效。建立2型糖尿病大鼠模型，每日给予苹果酸铬治疗，持续4周。采用大鼠酶联免疫吸附测定试剂盒测定大鼠糖代谢、糖代谢相关酶水平和脂质代谢变化。结果表明，苹果酸铬的抗高血糖活性以剂量依赖性方式增强。 17.5、20.0和20.8μg铬/kg体重的苹果酸铬组血清胰岛素水平、胰岛素抵抗指数和C肽水平显着低于模型组、三氯化铬组和吡啶甲酸铬组。 17.5、20.0和20.8μg铬/kg体重剂量下的苹果酸铬组的肝糖原、葡萄糖-6-磷酸脱氢酶和葡萄糖激酶水平显着高于模型组、三氯化铬组和吡啶甲酸铬组。与三氯化铬和吡啶甲酸铬组相比，20.0和20.8微克铬/公斤体重的苹果酸铬显着改变了总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯水平。结果表明，苹果酸铬在治疗2型糖尿病方面表现出更大的效益，且疗效优于三氯化铬和吡啶甲酸铬。
The present study was designed to evaluate the effect of chromium malate on glycometabolism, glycometabolism-related enzyme levels and lipid metabolism in type 2 diabetic rats, and dose–response and curative effects. The model of type 2 diabetes rats was developed, and daily treatment with chromium malate was given for 4 weeks. A rat enzyme-linked immunosorbent assay kit was used to assay glycometabolism, glycometabolism-related enzyme levels and lipid metabolism changes. The results showed that the antihyperglycemic activity increased with administration of chromium malate in a dose–dependent manner. The serum insulin level, insulin resistance index and C-peptide level of the chromium malate groups at a dose of 17.5, 20.0 and 20.8 μg chromium/kg bodyweight were significantly lower than that of the model, chromium trichloride and chromium picolinate groups. The hepatic glycogen, glucose-6-phosphate dehydrogenase and glucokinase levels of the chromium malate groups at a dose of 17.5, 20.0 and 20.8 μg chromium/kg bodyweight were significantly higher than that of the model, chromium trichloride and chromium picolinate groups. Chromium malate at a dose of 20.0 and 20.8 μg chromium/kg bodyweight significantly changed the total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides levels compared with the chromium trichloride and chromium picolinate groups. The results showed that chromium malate exhibits greater benefits in treating type 2 diabetes, and the curative effect of chromium malate is superior to chromium trichloride and chromium picolinate.