ALTERATIONS OF LIPID-METABOLISM IN HEALTHY VOLUNTEERS DURING LONG-TERM ETHANOL INTAKE
ALTERATIONS OF LIPID-METABOLISM IN HEALTHY VOLUNTEERS DURING LONG-TERM ETHANOL INTAKE
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DOI：
10.1111/j.1365-2362.1977.tb01584.x
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发表时间：
1977-01-01
影响因子：
5.5
通讯作者：
WIEBE, T
中科院分区：
文献类型：
--
作者：
BELFRAGE, P;BERG, B;WIEBE, T
9名年轻健康男性志愿者被给予乙醇（75 g/天）5周。将乙醇分成5个每日剂量并服用，使得血液乙醇水平从未超过0.04%（wt/vol）。在酒精摄入期的后半部分，血浆甘油三酯（TG）浓度显著一过性升高，随后降至正常水平。脂肪组织活检标本中脂蛋白脂酶活性（LLA）增加3倍。α的增加，在乙醇摄入期间还观察到脂蛋白浓度，其与血浆TG水平的降低和脂肪LLA的增加显著相关。在血浆胆固醇和β-胆固醇中没有观察到变化。脂蛋白水平肝活检标本中TG浓度一过性增加3倍。活组织检查标本的超微结构和细胞化学检查显示平滑内质网增生，γ-微管活性增加。谷氨酰转移酶（γ-在大多数受试者接近乙醇摄入期结束时和之后，血清γ- GT水平也显著增加。
Nine young, healthy male volunteers were given ethanol (75 g/day) for 5 wk. The ethanol was divided into 5 daily doses and taken so that blood ethanol levels never exceeded 0.04% (wt/vol). During the latter part of the ethanol intake period, there was a significant, transient increase of plasma triglyceride (TG) concentrations followed by reduction to normal levels. A 3-fold increase of lipoprotein lipase activity (LLA) occurred in biopsy specimens of adipose tissue. An increase of .alpha.-lipoprotein concentrations, which correlated significantly with the decrease in plasma TG levels and the increase in adipose LLA, was also observed during the ethanol intake period. No changes were observed in plasma cholesterol and .beta.-lipoprotein levels. A transient, 3-fold increase of TG concentrations occurred in liver biopsy specimens. Ultrastructural and cytochemical examinations of the biopsy specimens showed hyperplasia of the smooth endoplasmic reticulum, and increased canallicular activity of .gamma.-glutamyl transferase (.gamma.-GT) activity in most subjects towards the end of and after the ethanol intake period. Serum .gamma.-GT levels also increased significantly.