Preparation and characterization of Ca-alginate microspheres by a new emulsification method
Preparation and characterization of Ca-alginate microspheres by a new emulsification method
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DOI：
10.1016/s0378-5173(98)00063-5
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发表时间：
1998-08-01
影响因子：
5.8
通讯作者：
Nastruzzi, C
中科院分区：
文献类型：
--
作者：
Fundueanu, G;Esposito, E;Nastruzzi, C
以海藻酸为原料，用过量的氢氧化钠处理，然后用高浓度的CaCl2溶液处理，制备了海藻酸钙微球，并对其进行了表征。所得颗粒呈球形，平均直径为350微米，与已报道的海藻酸盐微胶囊(体积密度为0.47g/cm(3))相比，颗粒的内部结构相对致密、均匀，因此颗粒基质具有高密度的带电羧基。当接触时间为1h时，制得的粒子的交联度为54%。微球具有良好的稳定性，尽管它的溶胀度很低，但它具有很好的溶剂回收性，以及良好的阳离子药物结合能力。制备后的微球通过离子络合的方式与抗肿瘤的芳香族四氢呋喃进行负载。此外，还对药物的体外释放进行了研究。(C)1998 Elsevier Science B.V.保留所有权利。
The preparation and characterization of Ca-alginate microspheres obtained by a new procedure from alginic acid, treated with an excess of NaOH and subsequently with a very concentrated solution of CaCl2 are described. The produced particles have a spherical shape with an average diameter of 350 mu m. The particles show a relative dense and homogeneous internal structure in comparison with previously reported alginate microcapsules (the bulk density being 0.47 g/cm(3)), consequently the particle matrix is characterized by a high density of charged carboxylic groups. Particles produced with a contact time of 1 h showed a degree of crosslinking of 54%. Microspheres have a good stability, and despite of very low degree of swelling, they have a good solvents regain, and an excellent ionic binding capacity of cationic drugs. After preparation the beads were loaded by ionic complexation with an antitumor aromatic tetramidine. In addition, the in vitro release of drug has been studied. (C) 1998 Elsevier Science B.V. All rights reserved.