Dopamine mediation of positive reinforcing effects of amphetamine in stimulant naive healthy volunteers: results from a large cohort
Dopamine mediation of positive reinforcing effects of amphetamine in stimulant naive healthy volunteers: results from a large cohort
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DOI：
10.1016/j.euroneuro.2003.08.007
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发表时间：
2003-12-01
影响因子：
5.6
通讯作者：
Laruelle, M
中科院分区：
文献类型：
--
作者：
Abi-Dargham, A;Kegeles, LS;Laruelle, M
第一次接触滥用药物时的积极体验预示着随后的使用，可能是形成成瘾的一个脆弱因素。本文对60名健康志愿者进行了低剂量安非他明挑战（0.3 mg/kg，i. v.）在使用SPECT和D-2/D-3放射性示踪剂[I-123]IBZM进行多巴胺D-2受体可用性成像期间。安非他明刺激的DA释放诱导纹状体D-2受体可用性的小的、显著的和高度可变的降低（-8.3 +/-6.7%）。D-2受体可用性降低的幅度与受试者报告的药物的正强化作用显著相关（r（2）= 0.14，p = 0.003）。年龄与多巴胺引起积极强化效应的能力下降有关。这项研究表明，大的多巴胺能反应和年轻的年龄在第一次遇到一种药物的滥用潜力，有助于更高的积极加强作用。(C)2003年Elsevier B. V./ ECNP。All rights reserved.
A positive experience during a first encounter with a drug of abuse is predictive of subsequent use and might represent a vulnerability factor to develop addiction. This paper presents a meta-analysis of data acquired in 60 healthy volunteers who underwent a low-dose amphetamine challenge (0.3 mg/kg, i.v.) during imaging of dopamine D-2 receptor availability with SPECT and the D-2/D-3 radiotracer [I-123]IBZM. Amphetamine-stimulated DA release induced a small, significant and highly variable decrease in striatal D-2 receptor availability (-8.3 +/- 6.7%). The magnitude of the decrease in D-2 receptor availability was significantly associated with the positive reinforcing effects of the drug reported by the subject (r(2) = 0.14, p = 0.003). Age was associated with decreased potency of dopamine to elicit positive reinforcing effects. This study indicates that both a large dopaminergic response and young age during a first encounter with a drug of abuse potential contribute to higher positive reinforcing effects. (C) 2003 Elsevier B.V./ECNP. All rights reserved.