Diet, nutrient supply, and tumor immune responses.
Diet, nutrient supply, and tumor immune responses.
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DOI：
10.1016/j.trecan.2023.06.003
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发表时间：
2023-07
期刊：
影响因子：
18.4
通讯作者：
C. McIntyre;Ayantu Temesgen;L. Lynch
中科院分区：
文献类型：
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作者：
C. McIntyre;Ayantu Temesgen;L. Lynch
营养物质是细胞功能所必需的。免疫细胞在复杂的肿瘤微环境(TME)中工作，具有独特的营养成分，面临着调整新陈代谢以支持效应功能的挑战。我们讨论了营养供应对肿瘤免疫功能的影响，免疫细胞和肿瘤细胞之间对营养的竞争，以及饮食如何改变这一点。了解哪些饮食可以促进抗肿瘤免疫反应可能会开启治疗的新纪元，在这个时代，饮食调整可以作为辅助手段来促进现有癌症治疗的成功。
Nutrients are essential for cell function. Immune cells operating in the complex tumor microenvironment (TME), which has a unique nutrient composition, face challenges of adapting their metabolism to support effector functions. We discuss the impact of nutrient availability on immune function in the tumor, competition between immune cells and tumor cells for nutrients, and how this is altered by diet. Understanding which diets can promote antitumor immune responses could open a new era of treatment, where dietary modifications can be used as an adjunct to boost the success of existing cancer therapies.