Second Generation Nanoporous Silicon Nitride Membranes for High Toxin Clearance and Small Format Hemodialysis
Second Generation Nanoporous Silicon Nitride Membranes for High Toxin Clearance and Small Format Hemodialysis
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DOI：
10.1002/adhm.201900750
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发表时间：
2020-01-15
影响因子：
10
通讯作者：
Johnson, Dean G.
中科院分区：
文献类型：
--
作者：
Hill, Kayli;Walker, Samuel N.;Johnson, Dean G.
传统的血液透析 (HD) 使用落地式仪器和庞大的透析盒，其中包含约 2 m(2) 的 10 微米厚的曲折路径膜。便携式和可穿戴式 HD 系统可以通过促进更频繁、更长时间的在家透析、提供更多的生理毒素清除来改善终末期肾病患者的预后。开发具有这些优点的设备需要高效的膜来清除小尺寸的临床相关毒素。这里，超薄的能力（
Conventional hemodialysis (HD) uses floor-standing instruments and bulky dialysis cartridges containing approximate to 2 m(2) of 10 micrometer thick, tortuous-path membranes. Portable and wearable HD systems can improve outcomes for patients with end-stage renal disease by facilitating more frequent, longer dialysis at home, providing more physiological toxin clearance. Developing devices with these benefits requires highly efficient membranes to clear clinically relevant toxins in small formats. Here, the ability of ultrathin (