Granules in glial cells of patients with Alzheimer's disease are immunopositive for C-terminal sequences of beta-amyloid protein
Granules in glial cells of patients with Alzheimer's disease are immunopositive for C-terminal sequences of beta-amyloid protein
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DOI：
10.1016/s0304-3940(96)12474-5
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发表时间：
1996-03-15
影响因子：
2.5
通讯作者：
McGeer, PL
中科院分区：
文献类型：
--
作者：
Akiyama, H;Schwab, C;McGeer, PL
被特异性针对β-淀粉样蛋白（A β）片段的C-末端而非N-末端序列的抗体识别的颗粒结构存在于阿尔茨海默氏病脑组织中的小胶质细胞和星形胶质细胞的子集中。免疫组化结果表明，这些颗粒中的A β在残基17和31之间被截短，并终止于残基42或43处，这种含有颗粒的胶质细胞仅出现在具有大量A β沉积物的脑区域。胶质内A β片段是否是由于吞噬细胞外A β而积聚，还是由淀粉样前体蛋白（APP）在胶质细胞内形成，仍不清楚。
Granular structures that are recognized by antibodies specific for the C-terminal but not the N-terminal sequences of the beta-amyloid protein (A beta) fragments are present in a subset of microglia and astrocytes in Alzheimer brain tissue. The immunohistochemical profile indicates that the A beta in these granules is truncated between the residues 17 and 31 and terminates at the residue 42 or 43, Such granule-containing glia occur only in brain areas with the heavy A beta deposits. Whether the intraglial A beta fragments accumulate as a result of phagocytosis of extracellular A beta or are formed intracellularly by glial cells from amyloid precursor protein (APP) remains unknown.