Functional MRI of human amygdala activity during Pavlovian fear conditioning: Stimulus processing versus response expression
Functional MRI of human amygdala activity during Pavlovian fear conditioning: Stimulus processing versus response expression
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DOI：
10.1037/0735-7044.117.1.3
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发表时间：
2003-02-01
影响因子：
1.9
通讯作者：
Helmstetter, FJ
中科院分区：
文献类型：
--
作者：
Cheng, DT;Knight, DC;Helmstetter, FJ
Although laboratory animal studies have shown that the amygdala plays multiple roles in conditional fear, less is known about the human amygdala. Human subjects were trained in a Pavlovian fear conditioning paradigm during functional magnetic resonance imaging (fMRI). Brain activity maps correlated with reference waveforms representing the temporal pattern of visual conditional stimuli (CSs) and subject-derived autonomic responses were compared. Subjects receiving paired CS-shock presentations showed greater amygdala activity than subjects receiving Impaired CS-shock presentations when their brain activity was correlated with a waveform generated from their behavioral responses. Stimulus-based waveforms revealed learning differences in the visual cortex, but not in the amygdala. These data support the view that the amygdala is important for the expression of learned behavioral responses during Pavlovian fear conditioning.
