The spectrum of adult congenital heart disease in Europe:: morbidity and mortality in a 5 year follow-up period -: The Euro Heart Survey on adult congenital heart disease
The spectrum of adult congenital heart disease in Europe:: morbidity and mortality in a 5 year follow-up period -: The Euro Heart Survey on adult congenital heart disease
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DOI：
10.1093/eurheartj/ehi396
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发表时间：
2005-11-01
影响因子：
39.3
通讯作者：
Mulder, B
中科院分区：
文献类型：
--
作者：
Engelfriet, P;Boersma, E;Mulder, B
目的描述欧洲队列成人先天性心脏病（CHD）基线的临床和人口统计学特征，并评估死亡率和发病率在5年随访periods.Methods和结果作为欧洲心脏调查的一部分收集的数据对成人CHD进行了分析。这需要从4110名被诊断患有八种先天性心脏病（“缺陷”）之一的患者的档案中转录的信息，这些患者在1998年连续访问了其中一个参与中心的门诊部。这些患者被回顾性纳入，并随访至2003年底，中位随访时间为5.1年。尽管在随访期间他们的总体功能分级相对较好，死亡率较低，但相当比例的患者有心内膜炎、心律失常或血管事件病史。有八个缺陷之间的重大差异，无论是在发病率和具体特征。结果最差的紫绀缺陷和Fontan循环，但相当比例的其他患者也患有心脏症状。特别是，心律失常是common.Conclusion成人CHD在欧洲出现的频谱从这次调查是一个主要的年轻人口与大量的发病率，但在5年内死亡率相对较低。
Aims To describe clinical and demographic characteristics at baseline of a European cohort of adults with congenital heart disease (CHD) and to assess mortality and morbidity in a 5 year follow-up period.Methods and results Data collected as part of the Euro Heart Survey on adult CHD was analysed. This entailed information transcribed from the files of 4110 patients diagnosed with one of eight congenital heart conditions ('defects'), who consecutively visited the outpatient clinics of one of the participating centres in 1998. The patients were included retrospectively and followed until the end of 2003 for a median follow-up of 5.1 years. Notwithstanding their overall relatively good functional class and low mortality over the follow-up period, a considerable proportion of the patients had a history of endocarditis, arrhythmias, or vascular events. There were major differences between the eight defects, both in morbidity and regarding specific characteristics. Outcomes were worst in cyanotic defects and in the Fontan circulation, but a considerable proportion of the other patients also suffer from cardiac symptoms. In particular, arrhythmias are common.Conclusion The spectrum of adult CHD in Europe emerging from this survey is one of a predominantly young population with substantial morbidity but relatively low mortality in a 5 year period.