Social stimuli interfere with cognitive control in autism
Social stimuli interfere with cognitive control in autism
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DOI：
10.1016/j.neuroimage.2006.12.038
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发表时间：
2007-04-15
期刊：
影响因子：
5.7
通讯作者：
Belger, Aysenil
中科院分区：
文献类型：
--
作者：
Dichter, Gabriel S.;Belger, Aysenil
自闭症谱系障碍的特征是认知控制缺陷以及社会交往障碍。然而，大脑机制介导的相互作用的影响，这些赤字尚未得到解决。我们采用事件相关功能磁共振成像（fMRI）来研究处理来自面部的方向信息对大脑区域内调节认知控制的活动的影响。高功能自闭症患者和年龄、性别和智商匹配的神经型个体注意中央呈现的箭头或凝视刺激的方向，类似的侧翼刺激朝向相同（“一致”）或相反（“不一致”）的方向。不一致的箭头条件进行了检查，以评估功能的大脑区域介导的认知控制在没有社会认知需求的背景下，而不一致的凝视条件评估功能的相同的大脑区域在社会认知的背景下。与先前的研究一致，不一致的箭头条件招募活动在双侧额中回，右额下回，双侧顶内沟，前扣带回相对于一致的箭头条件在神经型参与者。值得注意的是，没有诊断组差异的模式，区域功能磁共振成像激活响应箭头条件。然而，在观看不一致的凝视刺激时，尽管神经典型的参与者招募了相同的大脑区域，但自闭症参与者在这些区域表现出明显的低激活。这些发现表明，处理社会认知刺激干扰了自闭症患者在认知控制任务中招募的大脑区域的功能。对自闭症认知控制缺陷研究的意义进行了讨论。(C)3 2007年爱思唯尔公司All rights reserved.
Autism spectrum disorders are characterized by cognitive control deficits as well as impairments in social interactions. However, the brain mechanisms mediating the interactive effects of these deficits have not been addressed. We employed event-related functional magnetic resonance imaging (fMRI) to examine the effects of processing directional information from faces on activity within brain regions mediating cognitive control. High-functioning individuals with autism and age-, gender-, and IQ-matched neurotypical individuals attended to the direction of a centrally-presented arrow or gaze stimulus with similar flanker stimuli oriented in the same ("congruent") or opposite ("incongruent") direction. The incongruent arrow condition was examined to assess functioning of brain regions mediating cognitive control in a context without social-cognitive demands, whereas the incongruent gaze condition assessed functioning of the same brain regions in a social-cognitive context. Consistent with prior studies, the incongruent arrow condition recruited activity in bilateral midfrontal gyrus, right inferior frontal gyrus, bilateral intraparietal sulcus, and the anterior cingulate relative to the congruent arrow condition in neurotypical participants. Notably, there were not diagnostic group differences in patterns of regional fMRI activation in response to the arrow condition. However, while viewing the incongruent gaze stimuli, although neurotypical participants recruited the same brain regions, participants with autism showed marked hypoactivation in these areas. These findings suggest that processing social-cognitive stimuli interferes with functioning of brain regions recruited during cognitive control tasks in autism. Implications for research into cognitive control deficits in autism are discussed. (C)3 2007 Elsevier Inc. All rights reserved.