Multiple, independent, identical IS6110 insertions in Mycobacterium tuberculosis PPE genes

Multiple, independent, identical IS6110 insertions in Mycobacterium tuberculosis PPE genes
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DOI:
10.1016/j.tube.2009.08.001
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发表时间:
2009-11-01
期刊:
影响因子:
3.2
通讯作者:
Gey van Pittius, Nicolaas C.
Gey van Pittius, Nicolaas C.
中科院分区:
医学4区
文献类型:
--
作者:
McEvoy, Christopher R. E.;Warren, Robin M.;Gey van Pittius, Nicolaas C.

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IS6110 是在结核分枝杆菌复合体成员中发现的转座元件。 IS6110 优先整合区域发生在结核分枝杆菌基因组内,但该元件之前并未显示出任何序列特异性整合偏好。在这里,我们提供了多个独立的 IS6110 插入到 3 个 PPE 基因的高度同源 50 区域内相同或几乎相同的位置的证据。 (C) 2009 Elsevier Ltd. 保留所有权利。
IS6110 is a transposable element found in Mycobacterium tuberculosis complex members. Regions of preferential IS6110 integration occur within the M. tuberculosis genome but the element has not previously been shown to exhibit any sequence-specific integration preferences. Here we provide evidence for multiple independent IS6110 insertions into identical, or near-identical, positions within the highly homologous 50 region of 3 PPE genes. (C) 2009 Elsevier Ltd. All rights reserved.