Molecularly Imprinted Poly(thionine)-Based Electrochemical Sensing Platform for Fast and Selective Ultratrace Determination of Patulin
Molecularly Imprinted Poly(thionine)-Based Electrochemical Sensing Platform for Fast and Selective Ultratrace Determination of Patulin
复制标题
基于分子印迹聚硫堇的电化学传感平台，用于快速、选择性超痕量测定棒曲霉素
DOI：
10.1021/acs.analchem.8b05791
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发表时间：
2019-03-19
影响因子：
7.4
通讯作者：
Han, Zheng
中科院分区：
文献类型：
--
作者：
Huang, Qingwen;Zhao, Zhihui;Han, Zheng
本文介绍了一种基于表面功能单体定向策略的灵敏选择性分子印迹电化学传感器的构建方法。采用电聚合的方法，在PtNP-氮掺杂石墨烯（NGE）的预形成的硫氨酸尾部表面上生长了一种涂覆了paulin印迹铂纳米颗粒（PtNP）的聚硫氨酸薄膜，该薄膜对paulin分子具有高容量和快速的吸附动力学。硫氨酸不仅是分子印迹聚合物（MIP）的功能单体，而且是一种信号指示物。通过将PtNPs、NGE和硫氨酸的优异导电性与多信号放大相结合，提高了灵敏度。该传感器在0.002-2 ng mL（-1）范围内（R-2 = 0.995）具有良好的棒曲霉素检测性能，对棒曲霉素的检出限为0.001 ng mL（-1）。该传感器具有良好的稳定性、重复性和选择性。此外，在实际样品的分析中也证明了其应用的可行性，为合理设计基于mip的电化学传感器以检测越来越多的有害物质提供了新的策略。
An innovative approach based on a surface functional monomer-directing strategy for the construction of a sensitive and selective molecularly imprinted electrochemical sensor for patulin recognition is described. A patulin imprinted platinum nanoparticle (PtNP)-coated poly(thionine) film was grown on a preformed thionine tailed surface of PtNP-nitrogen-doped graphene (NGE) by electro-polymerization, which provided high capacity and fast kinetics to uptake patulin molecules. Thionine acted not only as a functional monomer for molecularly imprinted polymer (MIP), but also as a signal indicator. Enhanced sensitivity was obtained by combining the excellent electric conductivity of PtNPs, NGE, and thionine with multisignal amplification. The designed sensor displayed excellent performance for patulin detection over the range of 0.002-2 ng mL(-1) (R-2 = 0.995) with a detection limit of 0.001 ng mL(-1) for patulin. In addition, the resulting sensor showed good stability and high repeatability and selectivity. Furthermore, the feasibility of its applications has also been demonstrated in the analysis of real samples, providing novel tactics for the rational design of MIP-based electrochemical sensors to detect a growing number of deleterious substances.