Increased frequency of DR2 in patients with aplastic anaemia and increased DR sharing in their parents
Increased frequency of DR2 in patients with aplastic anaemia and increased DR sharing in their parents
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再生障碍性贫血患者 DR2 出现频率增加，其父母 DR 共享增加
DOI：
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发表时间：
1986
影响因子：
6.5
通讯作者：
B. Speck
中科院分区：
文献类型：
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作者：
B. Chapuis;V. V. von Fliedner;M. Jeannet;H. Merica;P. Vuagnat;A. Gratwohl;C. Nissen;B. Speck
对68例再生障碍性贫血患者及其父母和健康同胞进行HLA-A、B和DR抗原分型。在患者中，DR 2的比例过高。受影响儿童的父母在DR位点表现出增加的相容性。这种情况可能有利于与造血有关并位于HLA位点的隐性基因的表达。
68 patients with aplastic anaemia, their parents and healthy siblings were typed for HLA‐A, B and DR antigens. Among the patients there is an overrepresentation of DR2. The parents of affected children show an increased compatibility at the DR locus. This situation could favour the expression of recessive gene(s) involved in haematopoiesis and located in the HLA locus.
影响因子：
158.5
作者：
CHAMPLIN, R;HO, W;GALE, RP
通讯作者：
GALE, RP