The TMEM16A anion channel as a versatile regulator of vascular tone
The TMEM16A anion channel as a versatile regulator of vascular tone
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TMEM16A 阴离子通道作为血管张力的多功能调节器
DOI：
10.1126/scisignal.adk5661
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发表时间：
2023
影响因子：
7.3
通讯作者：
Tammaro P
中科院分区：
文献类型：
--
作者：
Tammaro P
TMEM16A通道在动脉平滑肌和收缩周细胞中是一个关键的去极化机制，在那里它被几种内源性收缩激动剂激活。在这一期的《科学信号》中，Mata-DABONET等人展示了TMEM16A在血管内皮细胞中对乙酰胆碱介导的血管松弛的先前未知的作用。总而言之，TMEM16A充当血管活动刺激的传感器，以实现血管张力的精细调节。
The TMEM16A channel represents a key depolarizing mechanism in arterial smooth muscle and contractile pericytes, where it is activated by several endogenous contractile agonists. In this issue ofScience Signaling, Mata-Daboinet al.demonstrate a previously unidentified role for TMEM16A in endothelial cells for acetylcholine-mediated vasorelaxation. Collectively, TMEM16A serves as a transducer of vasoactive stimuli to enable fine modulation of vessel tone.
影响因子：
19.6
作者：
Cil O;Chen X;Askew Page HR;Baldwin SN;Jordan MC;Myat Thwe P;Anderson MO;Haggie PM;Greenwood IA;Roos KP;Verkman AS
通讯作者：
Verkman AS
DOI：
10.1152/ajpheart.00241.2009
发表时间：
2009-09-01
影响因子：
4.8
作者：
Earley, Scott;Pauyo, Thierry;Brayden, Joseph E.
通讯作者：
Brayden, Joseph E.