[Progress in bacterial urease complexes and their activation mechanisms].
[Progress in bacterial urease complexes and their activation mechanisms].
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DOI：
10.13345/j.cjb.180239
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发表时间：
2019-02-25
期刊：
影响因子：
--
通讯作者：
Wang, Jiaqi
中科院分区：
文献类型：
--
作者：
Li, Xiaojiao;Zhao, Shengguo;Wang, Jiaqi
脲酶将尿素分解为氨，在农业和医疗方面具有应用潜力。尿素酶蛋白包括结构蛋白（UreA、UreB和UreC）和辅助蛋白（UreD/UreH、UreE、UreF和UreG），它们在尿素酶成熟过程中具有各自独特的作用。结构蛋白是尿素酶的活性中心，辅助蛋白则负责镍的转运。我们在这里回顾了细菌尿素酶复合物的结构和功能，以及每种蛋白质如何相互作用以完成激活过程。以期为脲酶活性的调控和脲酶抑制剂的开发提供理论依据。
Urease decomposes urea to ammonia, and has application potential in agriculture and medical treatment. Urease proteins include structural proteins (UreA, UreB and UreC) and accessory proteins (UreD/UreH, UreE, UreF and UreG), each of them has its own unique role in urease maturation. The structural proteins form the active center of urease, and the accessory proteins are responsible for the delivery of nickel. We review here the structure and function of bacterial urease complexes, and how each protein interacts to complete the activation process. We hope to provide theoretical basis for the regulation of urease activity and the development of urease inhibitors.