Changes in methylation pattern of NMDA receptor NR2B gene in cortical neurons after chronic ethanol treatment in mice
Changes in methylation pattern of NMDA receptor NR2B gene in cortical neurons after chronic ethanol treatment in mice
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DOI：
10.1016/j.molbrainres.2003.10.025
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发表时间：
2004-02-05
期刊：
影响因子：
--
通讯作者：
Ticku, MK
中科院分区：
文献类型：
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作者：
Ravindran, CRM;Ticku, MK
慢性乙醇处理产生的成年皮层和培养的胎儿皮层神经元的NR2B基因表达率的增加。为了确定NR2B基因表达上调的可能分子机制，我们研究了小鼠胎儿皮层神经元CpG岛的甲基化。我们的研究结果表明，慢性乙醇给药导致皮层神经元CpG岛胞嘧啶残基的去甲基化，这可能是导致NR2B基因表达变化的原因。(C)2003 Elsevier B.V.保留所有权利。
Chronic ethanol treatment produced an increase in the rate of NR2B gene expression in adult cortex and cultured fetal cortical neurons. To determine the possible molecular mechanism involved in the upregulation of NR2B gene expression, we studied methylation in CpG island in mouse fetal cortical neurons. Our results demonstrate that chronic ethanol administration causes demethylation of cytosine residues in CpG island in cortical neurons which may be responsible for the changes in the expression of NR2B gene. (C) 2003 Elsevier B.V. All rights reserved.