Suppression of myocardial 18F-FDG uptake with a preparatory "Atkins-style" low-carbohydrate diet
Suppression of myocardial 18F-FDG uptake with a preparatory "Atkins-style" low-carbohydrate diet
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DOI：
10.1007/s00330-012-2478-2
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发表时间：
2012-10-01
影响因子：
5.9
通讯作者：
Abele, Jon
中科院分区：
文献类型：
--
作者：
Coulden, Richard;Chung, Peter;Abele, Jon
生理性心肌摄取18F-FDG在正电子发射断层扫描可以掩盖纵隔恶性肿瘤和炎症性心脏疾病的相邻异常摄取。心肌摄取是不可预测和可变的。本研究评估了低碳水化合物饮食对降低心肌FDG摄取的影响。要求参加临床肿瘤FDG PET检查的患者在检查前一天进行“阿特金斯式”低碳水化合物饮食（少于3 g），并整夜禁食。共120例患者低碳水化合物饮食加过夜禁食进行了比较，120例患者准备过夜禁食。阿特金斯饮食的患者还完成了饮食依从性调查问卷。测量两组心肌、血池和肝脏的SUVmax和SUVmean，心肌SUVmax从对照组的3.53 ± 2.91下降到饮食依从组的1.77 ± 0.91。98%的饮食依从性患者的心肌SUVmax小于3.6，而对照组为67%。肝脏和血池SUVmax从对照组的2.68 +/- 0.49和1.82 +/- 0.30上升到3.14 +/- 0.57和2.06 +/-0.30。有效抑制心肌FDG摄取。低碳水化合物饮食（LCD）PET前一天抑制心肌FDG摄取。PET前一天的Euro center LCD增加肝脏和血池SUV（最大）和SUV（平均）抑制心肌摄取可能改善胸部疾病的PET成像。抑制心肌摄取可能有助于PET对心脏炎性疾病的成像。
Physiological myocardial uptake of 18F-FDG during positron emission tomography can mask adjacent abnormal uptake in mediastinal malignancy and inflammatory cardiac diseases. Myocardial uptake is unpredictable and variable. This study evaluates the impact of a low-carbohydrate diet in reducing myocardial FDG uptake.Patients attending for clinically indicated oncological FDG PET were asked to have an "Atkins-style" low-carbohydrate diet (less than 3 g) the day before examination and an overnight fast. A total of 120 patients following low-carbohydrate diet plus overnight fast were compared with 120 patients prepared by overnight fast alone. Patients having an Atkins-style diet also completed a diet compliance questionnaire. SUVmax and SUVmean for myocardium, blood pool and liver were measured in both groups.Myocardial SUVmax fell from 3.53 +/- 2.91 in controls to 1.77 +/- 0.91 in the diet-compliant group. 98 % of diet-compliant patients had a myocardial SUVmax less than 3.6 compared with 67 % of controls. Liver and blood pool SUVmax rose from 2.68 +/- 0.49 and 1.82 +/- 0.30 in the control group to 3.14 +/- 0.57 and 2.06 +/- 0.30.An Atkins-style diet the day before PET, together with an overnight fast, effectively suppresses myocardial FDG uptake.aEuro cent Low-carbohydrate diet (LCD) the day before PET suppresses myocardial FDG uptake.aEuro cent LCD before PET increases liver and blood pool SUV (max) and SUV (mean) .aEuro cent Suppression of myocardial uptake may improve PET imaging of thoracic disease.aEuro cent Suppression of myocardial uptake may help imaging cardiac inflammatory disease with PET.