Acute alcohol intake alters resting state functional connectivity of nucleus accumbens with pain-related corticolimbic structures
Acute alcohol intake alters resting state functional connectivity of nucleus accumbens with pain-related corticolimbic structures
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DOI：
10.1016/j.drugalcdep.2019.107811
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发表时间：
2020-02-01
影响因子：
4.2
通讯作者：
Robinson, Michael E.
中科院分区：
文献类型：
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作者：
Boissoneault, Jeff;Stennett, Bethany;Robinson, Michael E.
背景：伏隔核（NAc）是奖励、强化和动机背后的腹侧纹状体结构，与广泛的情感处理结构（内侧前额叶皮层（mPFC）、杏仁核和岛叶）具有广泛的解剖和功能联系。表征急性酒精摄入如何影响伏隔核 (NAc) 和这些区域之间的静息态功能连接 (rsFC) 将提高对酒精神经行为影响的机制理解，包括急性酒精影响和疼痛处理之间的神经重叠。 方法：该研究纳入了 15 名健康的社交饮酒者（10 名女性；年龄：25-45 岁）。参与者完成了一个疗程，其中他们饮用了目标呼吸酒精浓度为 0.08 g/dL 的酒精剂量，并在第二个疗程中饮用了安慰剂饮料。每次训练期间饮用饮料后 30 - 35 分钟采集 9 分钟静息状态 fMRI 扫描。在饮料条件下比较 NAc 和先验皮质边缘感兴趣区域（mPFC、杏仁核和岛叶）之间的 rsFC。我们还对 NAc FC 进行了探索性全脑种子到体素分析。结果：酒精摄入减少了 NAc 和 mPFC 以及 NAc 和杏仁核之间的 rsFC。酒精还降低了 NAc 和 97 体素簇（包括双侧副扣带皮层和前扣带皮层）之间的 rsFC。 结论：研究结果表明，急性饮酒会降低 NAc 和健康社交饮酒者中 mPFC、杏仁核和头侧 ACC 等多个结构之间的 rsFC。这些结构是奖励、动机行为和情绪调节的基础，并且可以提供关于酒精如何影响相关过程（包括疼痛）的机制见解。
Background: The nucleus accumbens (NAc) is a ventral striatal structure underlying reward, reinforcement, and motivation, with extensive anatomic and functional connections to a wide range of affective processing structures (medial prefrontal cortex (mPFC), amygdala, and insula). Characterizing how acute alcohol intake affects resting state functional connectivity (rsFC) between the nucleus accumbens (NAc) and these regions will improve mechanistic understanding of alcohol's neurobehavioral effects, including the neural overlap between acute alcohol effects and pain processing.Methods: Fifteen healthy social drinkers (10 women; age: 25-45 years) were included in the study. Participants completed one session in which they consumed an alcohol dose targeting a breath alcohol concentration of 0.08 g/dL, and in a second a placebo beverage. Nine-minute resting state fMRI scans were acquired 30 - 35 min after beverage administration during each session. rsFC between NAc and a priori corticolimbic regions of interest (mPFC, amgydala, and insula), were compared between beverage conditions. We also conducted an exploratory whole-brain seed-to-voxel analysis of NAc FC.Results: Alcohol intake reduced rsFC between NAc and mPFC, as well as NAc and amygdala. Alcohol also reduced rsFC between NAc and a 97-voxel cluster including bilateral paracingulate cortex and anterior cingulate cortex.Conclusions: Findings suggest that acute alcohol intake reduces rsFC between NAc and several structures, including mPFC, amygdala, and rostral ACC in healthy social drinkers. These structures underlie reward, motivated behavior, and emotion regulation, and may provide mechanistic insight to how alcohol affects related processes, including pain.