Short Communication: Limited influence of haptoglobin genotypes on severe malaria in Ghanaian children
Short Communication: Limited influence of haptoglobin genotypes on severe malaria in Ghanaian children
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DOI：
10.1111/j.1365-3156.2005.01444.x
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发表时间：
2005-07-01
影响因子：
3.3
通讯作者：
Mockenhaupt, FP
中科院分区：
文献类型：
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作者：
Bienzle, U;Eggelte, TA;Mockenhaupt, FP
撒哈拉以南非洲的结合珠蛋白（Hp）多态性与严重疟疾风险增加有关。然而，现有数据并不确定。我们在加纳北方研究了Hp多态性在恶性疟原虫感染和严重疟疾易感性中的作用。研究了三组，每组290名年龄和性别匹配的重症疟疾儿童、无症状恶性疟原虫感染儿童和无血吸虫病健康对照儿童。Hp分型以PCR为基础。Hp 1 -1、Hp 2 -1和Hp 2 -2的检出率分别为32.4%、54.1%和13.5%。两组间Hp基因型的患病率无显著差异。然而，Hp 2等位基因在健康儿童中最不常见（0.379），在寄生虫病对照组中更常见（0.402），在重症疟疾患者中最常见（0.434; chi（2）（趋势）= 3.7; P = 0.06）。在配对分析中，没有Hp基因型增加严重疟疾的风险。然而，使用Hp 1 -1作为参考，Hp 2 -2的儿童表现出轻微增加的严重疟疾的风险（比值比，1.6; P = 0.04）。这些结果表明，幽门螺杆菌的多态性可能有一个相当有限的影响，严重疟疾的发展。
Haptoglobin (Hp) polymorphisms in sub-Saharan Africa have been associated with an increased risk of severe malaria. However, available data are inconclusive. We examined the role of Hp polymorphisms in susceptibility to Plasmodium falciparum infection and to severe malaria in northern Ghana. Three groups each of 290 age and sex-matched children with severe malaria, children with asymptomatic P. falciparum infection and aparasitaemic healthy controls were studied. Hp typing was based on PCR. In all children, Hp1-1, Hp2-1, and Hp2-2 occurred in 32.4%, 54.1%, and 13.5%, respectively. The prevalence of the Hp genotypes did not differ significantly between groups. However, Hp2 alleles were least common in healthy children (0.379), more frequent in parasitaemic controls (0.402), and most common in severe malaria patients (0.434; chi(2)(trend) = 3.7; P = 0.06). In matched pair analysis, no Hp genotype increased the risk of severe malaria. However, using Hp1-1 as a reference, children with Hp2-2 exhibited a slightly increased risk of severe malaria (odds ratio, 1.6; P = 0.04). These results indicate that Hp polymorhisms may have a rather limited influence on the development of severe malaria.