The Continued Promise of Neuroprotection for Acute Stroke Treatment.
The Continued Promise of Neuroprotection for Acute Stroke Treatment.
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DOI：
10.6030/1939-067x-1.1.1
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
Shimin Liu;S. Levine
中科院分区：
文献类型：
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作者：
Shimin Liu;S. Levine
中风是第二大致死原因。然而，有效的药物学治疗选择仍然极其有限，只适用于一小部分专利。在寻找有效的缺血性卒中神经保护剂方面的翻译失败在这一领域引起了积极的讨论。其中一个重点是验证测试神经保护剂的系统。本文就实验性卒中中一些值得进一步探讨的基本问题作一综述。我们首先对实验性卒中研究的现状进行综述，然后讨论控制和区分缺血细胞和组织命运的决定因素和过程。我们提出了几种针对缺血性中风的神经保护策略，重点是操纵细胞的能量状态。
Stroke is the second leading cause of death. However, effective pharmocologic treatment options are still extremely limited and applicable to only a small fraction of patents. The translational failure in finding an effective neuroprotectant for ischemic strokes has generated an active discussion in this field. One focus has been on validating systems for testing neuroprotectants. This review discusses some fundamental issues in experimental stroke that are worthy of further exploration. We begin with a general review of the current status of experimental stroke research and then move on to a discussion of the determining factors and processes that control and differentiate the fate of ischemic ischemic cells and tissue. We propose several strategies of neuroprotection for ischemic strokes with an emphasis on manipulating cellular energy state.