ULTRATHIN SILICON MEMBRANES FOR IMPROVING EXTRACORPOREAL BLOOD THERAPIES.
ULTRATHIN SILICON MEMBRANES FOR IMPROVING EXTRACORPOREAL BLOOD THERAPIES.
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用于改善体外血液治疗的超薄硅膜。
DOI：
10.1115/icnmm2016-8052
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
McGrath,James
中科院分区：
文献类型：
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作者：
Burgin,Tucker;Johnson,Dean;Chung,Henry;ClarkJr,Alfred;McGrath,James
体外血液疗法，如血液透析和体外膜氧合，通过血液和另一种液体之间的分子交换，通过半透膜来补充或替代器官功能。传统上，这些膜是由具有大表面积和微米级厚度的聚合物制成的。在这些装置中，治疗性气体交换或毒素清除主要是通过扩散发生的，这一过程可以用平方反比定律来描述，该定律与扩散粒子移动该距离所需的平均时间有关。因此，膜厚度或其他器件尺寸的微小变化可能会对器件性能产生重大影响，而大的变化可能会导致剧烈的范式转变。在这项工作中，我们讨论了厚度在几十纳米尺度上的超薄纳米多孔硅膜（纳米膜）在扩散介导的医疗器械中的应用。我们讨论了纳米膜医疗设备对患者的理论影响，分析了几个显着的好处，如减小设备尺寸（例如使可穿戴性）和提高清除特异性。特别关注描述真实实验行为的计算和分析模型，并在此过程中提供对控制设备的相关参数的见解。
Extracorporeal blood therapies such as hemodialysis and extracorporeal membrane oxygenation supplement or replace organ function by the exchange of molecules between blood and another fluid across a semi-permeable membrane. Traditionally, these membranes are made of polymers with large surface areas and thicknesses on the scale of microns. Therapeutic gas exchange or toxin clearance in these devices occurs predominantly by diffusion, a process that is described by an inverse square law relating a distance to the average time a diffusing particle requires to travel that distance. As such, small changes in membrane thickness or other device dimensions can have significant effects on device performance — and large changes can cause dramatic paradigm shifts. In this work, we discuss the application of ultrathin nanoporous silicon membranes (nanomembranes) with thicknesses on the scale of tens of nanometers to diffusion-mediated medical devices. We discuss the theoretical consequences of nanomembrane medical devices for patients, analyzing several notable benefits such as reduced device size (enabling wearability, for instance) and improved clearance specificity. Special attention is paid to computational and analytical models that describe real experimental behavior, and that in doing so provide insights into the relevant parameters governing the devices.