Precision medicine: how multiomics will shape the future of inflammatory bowel disease?
Precision medicine: how multiomics will shape the future of inflammatory bowel disease?
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精准医学：多组学将如何塑造炎症性肠病的未来？
DOI：
10.1097/mog.0000000000000847
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发表时间：
2022-07-01
影响因子：
2.5
通讯作者：
Ananthakrishnan, Ashwin N.
中科院分区：
文献类型：
--
作者：
Borren, Nienke Z.;Ananthakrishnan, Ashwin N.
在这篇文章中，我们提供了在炎症性肠病(IBD)的治疗中在不同临床场景中检查多组图谱的研究概况。IBD是由于遗传、环境、微生物和免疫扰动之间的相互作用而产生的。高通量技术的获得以及与这类研究相关的成本的降低导致了越来越多的文献研究单个或多个基因组图谱在IBD管理中的作用。这类研究通常在IBD整体状况或特定临床情景(包括疾病进展或治疗反应)的背景下检查基因组(以及较少见的表观基因组)、转录组、代谢组、蛋白质组和肠道微生物元基因组。这些发现提供了重要的洞察力，使人们了解到每个隔室如何反映潜在的疾病病理生理过程，并反过来影响临床治疗的患者分层。炎症性肠病的多组学分析有可能在炎症性肠病的治疗中推进个性化精确医学领域的发展。
In this article, we provide an overview of studies examining multi-omic profiling in various clinical scenarios in the management of inflammatory bowel diseases (IBD) IBD arises as a result of an interplay between genetic, environmental, microbial, and immunologic perturbations. The access to high throughput technology as well as the decrease in costs associated with such studies has led to a growing wealth of literature examining the utility of single or multi-omic profiles in the management of IBD. Such studies have commonly examined the genome (and less frequently the epigenome), transcriptome, metabolome, proteome, and the gut microbial metagenome in the context of overall IBD status or specific clinical scenarios including the disease progression or response to treatment. The findings have provided important insight into how each of these compartments reflect underlying disease pathophysiologic processes and, in turn, can influence stratification of patients for clinical management. Multi-omic profiling in IBD has the potential to advance the field of personalized precision medicine in the management of inflammatory bowel diseases.