Mechanisms in proliferative vitreoretinopathy.
Mechanisms in proliferative vitreoretinopathy.
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DOI：
10.1016/s0896-1549(01)00008-6
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发表时间：
2002-03
期刊：
影响因子：
--
通讯作者：
Ivana K. Kim;J. Arroyo
中科院分区：
文献类型：
--
作者：
Ivana K. Kim;J. Arroyo
增殖性玻璃体视网膜病变的伤口愈合范例为研究该过程的病理学提供了多种途径。正在出现的情况是细胞因子、基质蛋白和金属蛋白酶的复杂相互作用影响细胞行为并导致不良视网膜周围膜的形成。将治疗集中于一个特定靶点似乎不太可能足以阻止导致增殖性玻璃体视网膜病变的整个细胞事件级联。相反，针对该过程的不同阶段并在适当的时间给予多种辅助药物可能会更成功地改善患者的视力结果。
The wound-healing paradigm for proliferative vitreoretinopathy has provided numerous avenues for investigation into the pathobiology of the process. The emerging picture is a complex interaction of cytokines, matrix proteins, and metalloproteinases influencing cell behavior and resulting in the formation of undesirable periretinal membranes. It seems unlikely that focusing therapy on one particular target will be sufficient to stop the entire cascade of cellular events leading to proliferative vitreoretinopathy. Rather, multiple adjunctive agents targeted at different stages of the process and given at the appropriate time might be more successful in achieving improved visual outcomes for patients.