Mucosal activity patterns as a basis for olfactory discrimination: comparing behavior and optical recordings
Mucosal activity patterns as a basis for olfactory discrimination: comparing behavior and optical recordings
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DOI：
10.1016/s0006-8993(03)02512-5
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发表时间：
2003-08-15
期刊：
影响因子：
2.9
通讯作者：
Yurco, P
中科院分区：
文献类型：
--
作者：
Kent, PF;Mozell, MM;Yurco, P
在超过半个世纪的许多研究表明，不同的气味产生个别不同的空间模式的神经受体活动的嗅觉粘膜。然而，这些不同的活动模式可能是嗅觉感知的神经代码的想法还没有得到直接的测试。在本研究中，使用操作技术，大鼠进行了训练，以区别识别五种气味的同源系列的等强度的直链醛，不同系列只有一个碳原子，即己醛，癸醛。老鼠识别出了五种气味中的每一种，正确识别率超过90%。确定了五种气味中任何一对之间的感知相似度。使用多维尺度技术（MDS）的相似性措施产生了一个二维的感知气味空间。光学技术被用来记录嗅觉粘膜的活动模式，响应于这些相同的五个等强度醛。由每种气味剂引起的粘膜活动揭示了在这些带内和跨这些带变化的单独不同的带状图案。更重要的是，谱带的相对微分响应度与链长有关。所有可能的对气味诱导的活动模式之间的相异性测量的MDS分析产生了一个二维的神经生理气味空间。进一步的分析表明，神经生理学和精神病理学确定的气味空间高度相关（F-1，F-39=23.9，P=零）。这些结果提供了额外的可信度的概念，气味诱导的粘膜活动模式可以作为基板的气味质量的感知。(C)2003 Elsevier B. V.保留所有权利。
In over half a century numerous studies have demonstrated that different odorants produce individually different spatial patterns of neural receptor activity on the olfactory mucosa. However, the thought that these differential activity patterns could be the neural code underlying olfactory perception has not been tested directly. In the present study using operant techniques, rats were trained to differentially identify five odors from a homologous series of iso-intensive straight-chain aldehydes that differed serially by only one carbon atom, viz. hexaldehyde to decaldehyde. The rats identified each of the five odorants with greater than 90% correct identification. The degree of perceptual similarity between any pair of the five odorants was determined. Using multidimensional scaling techniques (MDS) the similarity measures yielded a two-dimensional perceptual odorant space. Optical techniques were used to record the olfactory mucosal activity patterns in response to these same five iso-intensive aldehydes. The mucosal activity elicited by each odorant revealed individually distinct band-like patterns that varied both within and across these bands. More importantly, the relative differential responsivity of the bands was related to chain length. An MDS analysis of the dissimilarity measure between all possible pairs of odorant induced activity patterns yielded a two-dimensional neurophysiologic odorant space. Further analysis indicated that the neurophysiologic and psychophysically determined odorant spaces were highly correlated (F-1,F-39=23.9, P=nil). These results give additional credence to the concept that the odorant-induced mucosal activity patterns may serve as the substrate for the perception of odorant quality. (C) 2003 Elsevier B.V. All rights reserved.