A 1D-3D Hybrid Model of Patient-Specific Coronary Hemodynamics
A 1D-3D Hybrid Model of Patient-Specific Coronary Hemodynamics
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DOI：
10.1007/s13239-021-00580-5
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发表时间：
2021-09-30
影响因子：
1.8
通讯作者：
Diamond, Scott L.
中科院分区：
文献类型：
--
作者：
Gutierrez, Noelia Grande;Sinno, Talid;Diamond, Scott L.
目的冠状动脉血流受到动脉粥样硬化斑块形成、破裂和血栓形成等事件的影响，导致心肌缺血和梗死。狭窄处的高分辨率3D血流动力学数据对于模拟冠状动脉疾病中的剪切敏感性血栓形成事件至关重要。方法我们开发了一个混合的1D-3D模拟框架，以有效地计算患者特定的冠状动脉血流动力学。冠状动脉血流的1D模型耦合到感兴趣区域的基于图像的3D模型。该框架提供了降阶建模的优点，降低了全局计算成本，而不牺牲感兴趣的数量的准确性。结果我们验证了我们的1D-3D模型对健康和患病条件下的全3D冠状动脉模拟。我们的研究结果表明，3D和1D-3D模型之间具有良好的一致性，同时与3D模拟相比，计算成本降低了40倍。1D-3D模型预测左/右冠状动脉血流分布在3%以内，并提供了与3D模拟相当的狭窄处血流储备分数和壁面切应力分布的准确估计。结论在几何形状变化的情况下，如血栓形成，计算成本的节省可能是显着的。此外，这种方法将允许量化血栓生长和闭塞对全球冠状动脉循环的时间依赖性影响。
Purpose Coronary flow is affected by evolving events such as atherosclerotic plaque formation, rupture, and thrombosis, resulting in myocardial ischemia and infarction. Highly resolved 3D hemodynamic data at the stenosis is essential to model shear-sensitive thrombotic events in coronary artery disease. Methods We developed a hybrid 1D-3D simulation framework to compute patient-specific coronary hemodynamics efficiently. A 1D model of the coronary flow is coupled to an image-based 3D model of the region of interest. This framework affords the advantages of reduced-order modeling, decreasing the global computational cost, without sacrificing the accuracy of the quantities of interest. Results We validated our 1D-3D model against full 3D coronary simulations in healthy and diseased conditions. Our results showed good agreement between the 3D and the 1D-3D models while reducing the computational cost by 40-fold compared to the 3D simulation. The 1D-3D model predicted left/right coronary flow distribution within 3% and provided an accurate estimation of fractional flow reserve and wall shear stress distribution at the stenosis comparable to the 3D simulation. Conclusion Savings in computational cost may be significant in situations with changing geometry, such as growing thrombosis. Also, this approach would allow quantifying the time-dependent effect of thrombotic growth and occlusion on the global coronary circulation.