Assessment of analytical methods used to measure changes in body composition in the elderly and recommendations for their use in phase II clinical trials
Assessment of analytical methods used to measure changes in body composition in the elderly and recommendations for their use in phase II clinical trials
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DOI：
10.1007/s12603-011-0049-x
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发表时间：
2011-05-01
影响因子：
5.8
通讯作者：
Fielding, R. A.
中科院分区：
文献类型：
--
作者：
Lustgarten, M. S.;Fielding, R. A.
据估计，在未来20年，65岁以上的人口数量将从4000万增加到7000万，占总人口的19%。与年龄相关的肌肉质量和功能下降，即肌肉减少症，已被证明与功能限制、虚弱以及发病率和死亡率的增加有关。因此，随着老年人口的增加，可以改善肌肉质量含量和/或功能的干预措施是必不可少的。然而，用于测量年轻受试者肌肉质量的分析技术可能不适用于老年人。因此，本综述的目的是检查用于测量老年受试者肌肉质量的常用方法的应用特异性和准确性，并为在促进功能的合成代谢疗法的II期临床试验中使用体成分测量方法提出具体建议。
It is estimated that in the next 20 years, the amount of people greater than 65 years of age will rise from 40 to 70 million, and will account for 19% of the total population Age-related decreases in muscle mass and function, known as sarcopenia, have been shown to be related to functional limitation, frailty and an increased risk of morbidity and mortality. Therefore, with an increasing elderly population, interventions that can improve muscle mass content and/or function are essential. However, analytical techniques used for measurement of muscle mass in young subjects may not be valid for use in the elderly. Therefore, the purpose of this review is to examine the applied specificity and accuracy of methods that are commonly used for measurement of muscle mass in aged subjects, and, to propose specific recommendations for the use of body composition measures in phase II clinical trials of function-promoting anabolic therapies.