Intestinal CD103- dendritic cells migrate in lymph and prime effector T cells
Intestinal CD103- dendritic cells migrate in lymph and prime effector T cells
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DOI：
10.1038/mi.2012.53
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发表时间：
2013-01-01
影响因子：
8
通讯作者：
Milling, S. W. F.
中科院分区：
文献类型：
--
作者：
Cerovic, V.;Houston, S. A.;Milling, S. W. F.
肠树突状细胞（DCs）通过淋巴管持续迁移至肠系膜淋巴结，并在那里启动免疫或耐受。最近的研究集中在表达CD 103的肠道DC群体。在这里，我们证明，第一次，在肠淋巴中存在两个不同的CD 103（-）DC亚群。与CD 103（+）DC类似，这些源自精氨酸的CD 103（-）DC对Flt 3有应答，并且它们有效地致敏并赋予初始T细胞肠道归巢表型。然而，在肠道DC中，CD 103（-）CD 11b（+）CX（3）CR 1（int）淋巴DC诱导产生干扰素-γ和白细胞介素-17的效应T细胞的分化，即使在没有明显刺激的情况下也是如此。通过CD 103（-）CD 11b（+）DCs的引发代表了肠道中效应T细胞应答快速产生的新机制。因此，这些细胞可能被证明是治疗肠道炎症或开发有效口服疫苗的有价值的靶点。
Intestinal dendritic cells (DCs) continuously migrate through lymphatics to mesenteric lymph nodes where they initiate immunity or tolerance. Recent research has focused on populations of intestinal DCs expressing CD103. Here we demonstrate, for the first time, the presence of two distinct CD103(-)DC subsets in intestinal lymph. Similar to CD103(+) DCs, these intestine-derived CD103(-) DCs are responsive to Flt3 and they efficiently prime and confer a gut-homing phenotype to naive T cells. However, uniquely among intestinal DCs, CD103(-) CD11b(+) CX(3)CR1(int) lymph DCs induce the differentiation of both interferon-gamma and interleukin-17-producing effector T cells, even in the absence of overt stimulation. Priming by CD103(-) CD11b(+) DCs represents a novel mechanism for the rapid generation of effector T-cell responses in the gut. Therefore, these cells may prove to be valuable targets for the treatment of intestinal inflammation or in the development of effective oral vaccines.