DNA polymorphism of immunoglobulin kappa confers risk of rheumatoid arthritis.
DNA polymorphism of immunoglobulin kappa confers risk of rheumatoid arthritis.
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免疫球蛋白 kappa 的 DNA 多态性会增加患类风湿性关节炎的风险。
DOI：
10.1002/anr.1780320518
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发表时间：
1989
影响因子：
--
通讯作者：
Moxley,G
中科院分区：
文献类型：
--
作者：
Moxley,G
为了验证与免疫球蛋白kappa恒定片段(Cκ)连锁的遗传因素导致类风湿性关节炎(RA)风险的假设，对患有RA的白人进行了SacI酶切位点多态性的检测。RA患者携带5/5kb Cκ基因的可能性高于白人对照组(相对危险度2.8，P<；0.0 2)。血清类风湿因子阳性的RA患者的相对危险度为2.4(P<；0.05)。无血清类风湿因子亚组的相对危险度更高，为9.7(P<；0.05)。提示免疫球蛋白kappa是类风湿关节炎遗传易感性的重要组成部分。
To examine the hypothesis that a hereditary factor linked to the immunoglobulin kappa constant segment (Cκ) contributes to risk of rheumatoid arthritis (RA), white persons with RA were examined forSacI restriction site polymorphisms. RA patients were more likely to have the 5/5‐kb Cκgenotype than white control subjects (relative risk 2.8,P< 0.02). A subgroup of RA patients who were positive for serum rheumatoid factor had a relative risk of 2.4 (P< 0.05). The subgroup without serum rheumatoid factor had an even higher relative risk of 9.7 (P< 0.05). The results suggest that immunoglobulin kappa is an important component in the genetic predisposition toward RA.